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Table 3 Logistic regression analysis for the association between the thyroid parameters and GDM in pre-pregnancy non-obese and obese subgroups

From: Maternal pre-pregnancy obesity modifies the association between first-trimester thyroid hormone sensitivity and gestational Diabetes Mellitus: a retrospective study from Northern China

 

Model 1

Model 2

Variable(1SD)

OR (95% CI)

P value

P for Interaction

OR (95% CI)

P value

P for Interaction

FT3

  

0.986

  

0.912

Non-obese

1.044 (0.890,1.225)

0.594

 

1.120 (0.946,1.325)

0.188

 

Obese

1.041 (0.750,1.445)

0.810

 

1.041 (0.729,1.486)

0.825

 

FT4

  

0.149

  

0.048

Non-obese

1.054 (0.900,1.235)

0.514

 

1.132 (0.959,1.335)

0.142

 

Obese

0.795 (0.561,1.127)

0.197

 

0.693 (0.470,1.021)

0.063

 

TSH

  

0.001

  

0.003

Non-obese

1.191 (1.023,1.388)

0.025

 

1.155 (0.980,1.362)

0.086

 

Obese

0.562 (0.372,0.850)

0.006

 

0.563 (0.368,0.863)

0.008

 

FT3/FT4 ratio

  

0.128

  

0.032

Non-obese

0.990 (0.843,1.162)

0.903

 

0.976 (0.823,1.158)

0.784

 

Obese

1.323 (0.944,1.853)

0.104

 

1.609 (1.082,2.395)

0.019

 

TFQI

  

< 0.001

  

< 0.001

Non-obese

1.199 (1.024,1.403)

0.024

 

1.250 (1.056,1.478)

0.009

 

Obese

0.552 (0.370,0.824)

0.004

 

0.474 (0.303,0.743)

0.001

 

PTFQI

  

0.001

  

0.001

Non-obese

1.191 (1.018,1.395)

0.030

 

1.240 (1.049,1.467)

0.012

 

Obese

0.570 (0.381,0.854)

0.006

 

0.494 (0.315,0.774)

0.002

 

TSHI

  

< 0.001

  

0.001

Non-obese

1.194 (1.016,1.404)

0.032

 

1.197 (1.007,1.422)

0.041

 

Obese

0.537 (0.357,0.807)

0.003

 

0.517 (0.333,0.802)

0.003

 

TT4RI

  

< 0.001

  

0.001

Non-obese

1.186 (1.020,1.378)

0.026

 

1.172 (0.996,1.379)

0.056

 

Obese

0.480 (0.304,0.757)

0.002

 

0.468 (0.292,0.752)

0.002

 
  1. Model 1: crude model
  2. Model 2: adjusted for age, parity, first-trimester TG, LDL-C, UA and eGFR.