Table 1 MiniMed™ 780G system settings, usability, and glucometrics among different age groups of patients with T1DM after Auto-mode initiation of AHCL system

BG calibration (n/day)

2.85 ± 1.02

2.84 ± 0.48

2.95 ± 1.10

2.81 ± 1.13

0.865

Average SG (mg/dL)

151.74 ± 16.87

146.00 ± 12.44

155.31 ± 17.74

145.14 ± 13.68

0.037

0.162

0.904

0.017

GMI (eA1C %)

GMI (eA1C mmol/moL)

6.95 ± 0.58

52.6 ± 7.5

6.73 ± 0.40

50.4 ± 7.4

7.0 ± 0.58

55.3 ± 7.9

6.71 ± 0.54

50.1 ± 7.3

0.005

0.006

0.031

0.033

0.992

0.991

0.024

0.025

CoV (%)

34.1 ± 8.3

35.2 ± 8.7

38.9 ± 9.8

32.7 ± 8.1

0.023

0.256

0.667

0.028

TIR 70–180 mg/dL (%)

81.54 ± 8.43

82.29 ± 7.22

78.4 ± 7.34

83.86 ± 9.24

0.010

0.113

0.791

0.018

TBR < 70 mg/dL (%)

2.19 ± 1.11

3.29 ± 1.50

1.88 ± 0.91

1.86 ± 0.98

< 0.001

< 0.001

< 0.001

0.995

TBR < 54 mg/dL (%)

0.54 ± 0.31

1.00 ± 0.69

0.29 ± 0.11

0.18 ± 0.09

< 0.001

< 0.001

< 0.001

0.366

TAR 180–250 mg/dL (%)

13.17 ± 6.15

12.71 ± 4.72

13.95 ± 6.12

11.6 ± 6.55

0.332

TAR > 250 mg/dL (%)

2.56 ± 1.21

0.71 ± 0.50

5.48 ± 2.22

2.50 ± 1.32

0.075

Total daily dose (U/day)

35.17 ± 11.42

12.24 ± 4.79

47.94 ± 10.72

45.35 ± 12.82

< 0.001

< 0.001

< 0.001

0.588

Bolus amount (U/day)

19.22 ± 8.76

8.23 ± 2.21

32.14 ± 9.46

24.94 ± 8.44

< 0.001

< 0.001

< 0.001

0.003

Auto correction amount (day)

6.53 ± 3.13

1.64 ± 0.32

7.07 ± 3.17

5.48 ± 2.86

< 0.001

< 0.001

< 0.001

0.070

Auto Basal/Basal amount (day)

15.95 ± 7.93

4.01 ± 1.95

15.80 ± 6.11

20.41 ± 8.98

< 0.001

< 0.001

< 0.001

0.012

Smart Gaurd /week Auto Mode (%)

85.31 ± 22.04

88.57 ± 23.46

82.71 ± 22.49

87.18 ± 22.17

0.507

Glucose target, n (%)

 100 mg dL (5.6 mmol/ L)

 110 mg dL (6.1 mmol/ L)

 120 mg dL (6.7 mmol/ L)

70 (65.4)

23 (21.5)

14 (13.1)

0 (0)

7 (33.3)

14 (66.7)

53 (80.3)

13 (19.7)

0 (0)

17 (85.0)

3 (15.0)

0 (0)

< 0.001

< 0.001

< 0.001

0.894

Sensor wear (%)

85.94 ± 19.00

90.71 ± 24.34

82.50 ± 21.24

86.04 ± 17.90

0.298

Active insulin time, n (%)

 2 h

 > 2 to 3 h

 > 3 to 4 h

 > 4 h

72 (67.3)

27 (25.23)

6 (5.61)

2 (1.86)

2 (9.5)

11 (52.4)

6 (28.6)

2 (9.5)

55 (83.3)

11 (16.7)

0 (0)

0 (0)

15 (75.0)

5 (25.0)

0 (0)

0 (0)

< 0.001

< 0.001

< 0.001

0.401

Carbohydrates (gr/day)

162 ± 33.2

132.6 ± 31.1

196.1 ± 39.3

150.4 ± 34.5

< 0.001

< 0.001

< 0.001

< 0.001

ICR (gr)

11.1 ± 2.9

16.6 ± 3.1

6.4 ± 2.1

7.3 ± 2.5

< 0.001

< 0.001

< 0.001

0.309

Exit from AHCL per patient (n/week)

1.0 ± 0.8

1 ± 0.5

2.0 ± 0.9

1 ± 0.6

< 0.001

< 0.001

0.715

< 0.001