Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats

Table 5 Correlations between IMAT magnetic-resonance parameters and laboratory indicators

	FBG		FINS		OGTT-AUC		HOMA-IR
	p	β	p	β	p	β	p	β
IMAT (%)	< 0.01	0.59	< 0.01	0.64	0.02	0.63	< 0.01	0.68
IMAT-T2 (ms)	0.03	0.50	0.03	0.47	0.02	0.45	0.01	0.56
IMAT-ADC (10^–3 mm²/s)	0.05*	0.51	< 0.01	0.51	0.04	0.40	< 0.01	0.49
IMAT-FA	0.04	− 0.45	0.04	− 0.47	0.04	− 0.50	0.02	− 0.51
Muscle-T2 (ms)	< 0.01	0.65	< 0.01	0.70	0.02	0.50	< 0.01	0.78
Muscle-ADC (10^–3 mm²/s)	0.04	0.35	0.01	0.53	0.05*	0.38	< 0.01	0.60
Muscle-FA	0.03	− 0.47	0.05*	− 0.45	0.04	− 0.50	0.01	− 0.53
IMCL/Cr	0.49	0.13	0.01	0.50	0.05*	0.38	0.08	0.32

ADC apparent-diffusion coefficient, Cr creatine, FA fractional anisotropy, FINS fasting insulin, HOMA-IR homeostatic model assessment of insulin resistance, IMAT intermuscular adipose tissue, IMCL intra-myocellular lipid, T2 transverse relaxation time 2
*0.045 < p < 0.050

ISSN: 1758-5996