Fig. 2

Alterations in body weight and glucose homeostasis indicate the development of prediabetes with high-fat-diet and high-sugar-drink at week 10. A Changes in body weights during the experiment. B Body-weight data after 10 weeks. C Homeostatic model assessment of insulin resistance (HOMA-IR) at week 10. D, E Fasting-blood glucose levels (D) throughout the experiment and at week 10 (E). F–H 2 h oral glucose tolerance test (OGTT) area under the curve (AUC) values (G, H), fasting-blood insulin levels (F), and chow intake results (I) at week 10 of the diet. The data shown represent the mean ± standard error of the mean. Control (CON) group, n = 6; prediabetic (PRE) group, n = 30; Analyses were performed using two-way repeated ANOVA tests for FBG and body weight during week 0–10, and 2 h-OGTT. Student t-tests for body weight, HOMA-IR, FBG, FINS, OGTT AUC and Chow intake in week 10 (*p < 0.05, **p < 0.01, ***p < 0.001)