Table 2 The effect of empagliflozin on serum uric acid level based on different subgroups

Type of study

 RCT

− 2.41

− 3.83

− 0.99

< 0.001

99.7

 Observational

− 0.38

− 0.88

0.12

0.178

42.1

Time of treatment (weeks)

 ≤ 6

− 1.52

− 2.93

− 0.10

< 0.001

95

 12

− 1.53

− 2.72

− 0.35

< 0.001

92.3

 24

− 0.67

− 0.93

− 0.42

0.248

26

 164

− 7.15

− 7.39

− 6.92

< 0.001

92.8

Dosage (mg)

 10

− 2.20

− 5.22

0.81

< 0.001

99.8

 25

− 1.91

− 5.26

1.44

< 0.001

99.7