Association of triglyceride-glucose index with cardiovascular disease among a general population: a prospective cohort study

Table 3 Association between TyG index with the risk of cardiovascular disease according to subgroups

		CVD	P for interaction	Stroke	P for interaction	CHD	P for interaction
Subgroups	N	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Sex			0.555		0.919		0.967
Male	17,208	1.22 (1.06–1.41)	0.006	1.40 (1.16–1.70)	< 0.001	0.93 (0.75–1.15)	0.486
Female	25,447	1.08 (0.92–1.28)	0.342	1.35 (1.06–1.71)	0.015	0.85 (0.68–1.07)	0.157
Age			0.002		0.066		0.008
< 50	9,924	1.64 (1.12–2.42)	0.012	1.89 (1.09–3.26)	0.023	1.55 (0.83–2.86)	0.166
≥ 50	32,731	1.12 (1.00-1.25)	0.055	1.34 (1.15–1.56)	< 0.001	0.84 (0.71–0.99)	0.030
BMI			0.399		0.263		0.954
< 18.5	2,586	0.62 (0.20–1.94)	0.409	1.05 (0.25–4.41)	0.947	0.22 (0.04–1.33)	0.100
18.5–23.9	19,206	1.25 (1.04–1.50)	0.002	1.66 (1.29–2.12)	< 0.001	0.88 (0.67–1.16)	0.370
24.0-27.9	15,761	1.09 (0.93–1.27)	0.290	1.17 (0.93–1.46)	0.179	0.91 (0.73–1.14)	0.395
≥ 28	5,102	1.19 (0.92–1.54)	0.181	1.46 (1.04–2.04)	0.028	0.81 (0.56–1.17)	0.265
Hypertension			< 0.001		0.008		0.004
Yes	21,346	1.10 (0.97–1.24)	0.136	1.32 (1.11–1.57)	0.002	0.83 (0.69–0.99)	0.039
No	21,309	1.20 (0.97–1.49)	0.097	1.44 (1.06–1.95)	0.019	0.95 (0.69–1.29)	0.733
Diabetes			< 0.001		0.001		0.007
Yes	4,358	1.23 (1.02–1.48)	0.030	1.53 (1.20–1.95)	< 0.001	0.84 (0.63–1.12)	0.224
No	38,297	1.04 (0.91–1.19)	0.596	1.17 (0.96–1.42)	0.124	0.84 (0.69–1.01)	0.070
Dyslipidemia			0.007		0.277		0.008
Yes	14,773	1.02 (0.87–1.18)	0.836	1.28 (1.04–1.58)	0.020	0.71 (0.57–0.89)	0.002
No	27,882	1.17 (0.97–1.41)	0.112	1.43 (1.09–1.88)	0.010	0.91 (0.70–1.18)	0.473

h present risks in each subgroup per 1 unit higher TyG index
BMI, body mass index; CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; TyG, triglyceride-glucose
HRs were adjusted for age, sex, body mass index, education level, physical activity, current smoking, current drinking, high-density lipoprotein cholesterol, uric acid, antihypertensive medication and antidiabetic medication

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