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Table 2 Association between TyG index and incidence of cardiovascular diseases

From: Association of triglyceride-glucose index with cardiovascular disease among a general population: a prospective cohort study

Event

TyG

No. of cases/population

Incidence rate per 1000 person-years

Hazard ratio (95% CI)

Model 1

Model 2

Model 3

Model 4

CVD

Per 1 unit

1,422/42,651

 

1.54 (1.43–1.67)***

1.51 (1.39–1.63)***

1.43 (1.31–1.56)***

1.16 (1.04–1.29)**

 

Q1

262/10,662

4.95

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

 

Q2

296/10,663

5.72

1.16 (0.98–1.37)

1.07 (0.90–1.26)

1.01 (0.85–1.20)

0.95 (0.80–1.13)

 

Q3

368/10,663

7.21

1.46 (1.24–1.71)***

1.32 (1.13–1.55)***

1.22 (1.04–1.44)*

1.06 (0.89–1.25)

 

Q4

496/10,663

9.88

2.00 (1.72–2.32)***

1.80 (1.55–2.10)***

1.62 (1.39–1.90)***

1.18 (0.98–1.41)

Stroke

Per 1 unit

674/42,651

 

1.73 (1.55–1.93)***

1.71 (1.52–1.91)***

1.65 (1.46–1.86)***

1.39 (1.19–1.61)***

 

Q1

115/10,662

2.16

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

 

Q2

131/10,663

2.51

1.16 (0.90–1.49)

1.08 (0.84–1.39)

1.02 (0.79–1.32)

0.98 (0.75–1.26)

 

Q3

174/10,663

3.38

1.56 (1.23–1.97)***

1.43 (1.13–1.81)**

1.32 (1.04–1.69)*

1.18 (0.91–1.52)

 

Q4

254/10,663

5.01

2.30 (1.85–2.87)***

2.10 (1.69–2.63)***

1.93 (1.53–2.43)***

1.44 (1.10–1.88)**

CHD

Per 1 unit

732/42,651

 

1.28 (1.15–1.44)***

1.23 (1.09–1.38)***

1.13 (0.99–1.28)

0.99 (0.85–1.15)

 

Q1

149/10,662

2.80

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

 

Q2

168/10,663

3.22

1.15 (0.93–1.44)

1.05 (0.84–1.31)

1.00 (0.80–1.25)

0.93 (0.74–1.17)

 

Q3

191/10,663

3.71

1.33 (1.07–1.65)**

1.18 (0.95–1.46)

1.08 (0.87–1.35)

0.92 (0.73–1.16)

 

Q4

224/10,663

4.41

1.58 (1.29–1.95)***

1.41 (1.14–1.73)***

1.23 (0.99–1.53)

0.88 (0.70–1.13)

  1. Exact values of quartiles of TyG index are as follows: (Q1) ≤ 8.246, (Q2) ≤ 8.609 and > 8.246, (Q3) ≤ 9.020 and > 8.609, and (Q4) > 9.020
  2. *: P < 0.05; **: P < 0.01; ***: P < 0.001
  3. Model 1: unadjusted model
  4. Model 2: adjusted for age and sex
  5. Model 3: adjusted for age, sex, body mass index, education level, physical activity, current smoking and current drinking
  6. Model 4: adjusted for age, sex, body mass index, education level, physical activity, current smoking, current drinking, high-density lipoprotein cholesterol, uric acid, antihypertensive medication and antidiabetic medication
  7. CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; Q, quartiles; TyG, triglyceride-glucose
  8. P for trend was calculated by modelling TyG index as a continuous variable into Cox proportional model
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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