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Table 4 Sensitivity analyses for the association of ultra-processed (UPF) consumption with incident diabetes (n = 10,202)

From: Association between ultra-processed food consumption and the incidence of type 2 diabetes: the ELSA-Brasil cohort

 

Absolute increments

Quartile 2

Quartile 3

Quartile 4

 

RR (95% CI)

RR (95% CI)

RR (95% CI)

RR (95% CI)

Reclassifying natural juice/coffee/tea with added sweeteners as UPFs rather than as non- or minimally processed food

1.06 (1.04, 1.08)

1.04 (0.92, 1.18)

1.32 (1.17, 1.49)

1.40 (1.25, 1.58)

Defining daily UPF consumption as a proportion of the daily diet´s weight

1.06 (1.03, 1.10)

1.04 (0.92, 1.17)

1.09 (0.96, 1.23)

1.24 (1.10, 1.40)

Inclusion of red meat intake as an adjustment variable

1.05 (1.03, 1.07)

0.96 (0.85, 1.08)

1.02 (0.91, 1.15)

1.20 (1.07, 1.35)

Inclusion of fruit and vegetable intake as an adjustment variable

1.05 (1.03, 1.07)

0.96 (0.85, 1.08)

1.03 (0.91, 1.16)

1.23 (1.09, 1.38)

Inclusion of saturated fat intake as an adjustment variable

1.07 (1.05, 1.09)

0.98 (0.87, 1.11)

1.07 (0.95, 1.21)

1.32 (1.16, 1.50)

Inclusion of sugar intake as an adjustment variable

1.09 (1.06, 1.11)

0.99 (0.87, 1.11)

1.09 (0.96, 1.23)

1.37 (1.20, 1.56)

Inclusion of fiber intake as an adjustment variable

1.06 (1.04, 1.08)

0.97 (0.86, 1.09)

1.05 (0.93, 1.18)

1.27 (1.13, 1.43)

Inclusion of diet quality as an adjustment variable

1.06 (1.04, 1.09)

0.97 (0.86, 1.10)

1.05 (0.93, 1.19)

1.29 (1.15, 1.46)

Inclusion of 16 cases of incident diabetes who died and were excluded among deaths

1.05 (1.03, 1.07)

0.96 (0.85, 1.09)

1.03 (0.92, 1.17)

1.24 (1.11, 1.39)

Multiple imputation

1.04 (1.02, 1.06)

0.96 (0.86, 1.08)

1.02 (0.91, 1.15)

1.20 (1.07, 1.34)

  1. All analyses were performed with Model 2, as defined in Table 2
  2. Absolute increments: 7% was used for the “UPF consumption as a proportion of the daily diet´s weight” (10th percentile of consumption). 150 g/d increases were used for all the other analyses
  3. New quartiles for UPF consumption as a proportion of the daily diet´s weight analysis: quartile 1: reference; quartile 2: 10.8–16.2%; quartile 3: 16.3–23.4%; quartile 4: ≥ 23.5%
  4. New quartiles for reclassification analysis: quartile 1: reference; quartile 2: 273–436 g/day; quartile 3: 437–669 g/day; quartile 4: ≥ 670 g/day