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Table 2 Risk of incident stroke and its subtypes for baseline TyG index

From: Triglyceride–glucose index and the risk of stroke in American adults: findings from the atherosclerosis risk in communities study

Outcomes

TyG Index (as a categorical variable)

TyG Index (as a continuous variable)

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Stroke

 Events/No. at risk

171/2527

197/2539

243/2532

298/2534

909/10132

 Model 1

Reference

1.129 (0.920–1.387)

1.460 (1.199–1.778)**

1.876 (1.549–2.272)**

1.658 (1.486–1.849)**

 Model 2

Reference

1.059 (0.862–1.302)

1.292 (1.057–1.580)*

1.441 (1.171–1.774)**

1.439 (1.269–1.633)**

 Model 3

Reference

0.992 (0.805–1.221)

1.181 (0.962–1.449)

1.254 (1.014–1.552)*

1.321 (1.161–1.504)**

Ischemic stroke

 Events/No. at risk

129/2527

178/2539

213/2532

273/2534

793/10132

 Model 1

Reference

1.355 (1.079–1.701)*

1.691 (1.357–2.108)**

2.276 (1.840–2.816)**

1.811 (1.614–2.033)**

 Model 2

Reference

1.257 (1.001–1.579)*

1.471 (1.176–1.840)**

1.721 (1.370–2.161)**

1.527 (1.336–1.745)**

 Model 3

Reference

1.169 (0.929–1.472)

1.330 (1.059–1.670)*

1.480 (1.172–1.869)*

1.398 (1.219–1.603)**

Intracerebral hemorrhage

 Events/No. at risk

29/2527

15/2539

25/2532

26/2534

95/10132

 Model 1

Reference

0.530 (0.283–0.990)*

0.932 (0.543–1.600)

1.053 (0.612–1.813)

1.111 (0.774–1.595)

 Model 2

Reference

0.525 (0.280–0.986)*

0.914 (0.526–1.589)

1.117 (0.622–2.005)

1.170 (0.774–1.769)

 Model 3

Reference

0.494 (0.262–0.931)*

0.843 (0.479–1.484)

0.973 (0.533–1.779)

1.064 (0.695–1.629)

  1. Model 1, adjusted for baseline age, race-center and sex
  2. Model 2, adjusted for variables in model 1 plus baseline smoking status, alcohol status, body mass index, diabetes mellitus (time-varying), heart failure (time-varying) and peripheral artery disease (time-varying)
  3. Model 3, adjusted for variables in model 2 plus baseline systolic blood pressure, low-density lipoprotein cholesterol, estimated glomerular filtration rate, fibrinogen, lipid-lowering drugs and antihypertensive drugs
  4. TyG triglyceride–glucose
  5. * P < 0.05; **P < 0.001