Table 1 Baseline characteristics of the patients according to baseline Prognostic nutritional index and glucose metabolism statuses
| Â | Baseline PNI category | p value | Glucose metabolism statuses | p value | ||||
|---|---|---|---|---|---|---|---|---|
PNI-L (PNI ≤ 42.7) | PNI-M (> 42.7, ≤ 48.2) | PNI-H (> 48.2) | NGR | pre-DM | DM | |||
No. of subjects | 5910 | 5895 | 5856 | Â | 6914 | 4741 | 6006 | Â |
Age, years | 65.7 ± 11.4 | 61.5 ± 11.6 | 57.0 ± 11.9 | < 0.0001 | 60.8 ± 12.9 | 61.5 ± 11.7 | 62.0 ± 11.6 | < 0.0001 |
Age > 65, years | 3154 (53.4) | 2189 (37.1) | 1406 (24.0) | < 0.0001 | 2578 (37.3) | 1817 (38.3) | 2355 (39.2) | 0.0793 |
Female sex | 1226 (20.7) | 1092 (18.5) | 864 (14.8) | < 0.0001 | 1096 (15.9) | 705 (14.9) | 1381 (23.0) | < 0.0001 |
Current smoking, n (%) | 1699 (44.7) | 1582 (48.0) | 1630 (50.0) | < 0.0001 | 1992 (49.0) | 1485 (51.6) | 1435 (42.0) | < 0.0001 |
Hypertension, n (%) | 3025 (51.2) | 2817 (47.8) | 2577 (44.0) | < 0.0001 | 2880 (41.7) | 2129 (44.9) | 3412 (56.8) | < 0.0001 |
Glucose metabolism status |  |  |  | < 0.0001 |  |  |  | < 0.0001 |
NGR, n (%) | 2119 (35.9) | 2321 (39.4) | 2474 (42.3) | Â | 6914 (100.0) | NA | NA | Â |
pre-DM, n (%) | 1668 (28.2) | 1616 (27.4) | 1456 (24.9) | Â | NA | 4741 (100.0) | NA | Â |
DM, n (%) | 2123 (35.9) | 1957 (33.2) | 1925 (32.9) | Â | NA | NA | 6006 (100.0) | Â |
Congestive heart failure, n (%) | 2700 (45.7) | 1979 (33.6) | 1706 (29.1) | < 0.0001 | 2351 (34.0) | 1623 (34.2) | 2412 (40.2) | < 0.0001 |
Chronic kidney disease, n (%) | 2118 (35.8) | 1143 (19.4) | 754 (12.9) | < 0.0001 | 1322 (19.1) | 971 (20.5) | 1723 (28.7) | < 0.0001 |
Atrial fibrillation, n (%) | 297 (5.0) | 207 (3.5) | 136 (2.3) | < 0.0001 | 232 (3.4) | 164 (3.5) | 244 (4.1) | 0.0779 |
Proir stroke, n (%) | 469 (7.9) | 316 (5.4) | 241 (4.1) | < 0.0001 | 318 (4.6) | 246 (5.2) | 462 (7.7) | < 0.0001 |
Hyperlipemia, n (%) | 3626 (61.4) | 3620 (61.4) | 4124 (70.4) | < 0.0001 | 4195 (60.7) | 3136 (66.1) | 4040 (67.3) | < 0.0001 |
Anemia, n (%) | 3262 (55.2) | 1775 (30.1) | 820 (14.0) | < 0.0001 | 2158 (31.2) | 1504 (31.7) | 2197 (36.6) | < 0.0001 |
Proir PCI, n (%) | 264 (4.5) | 238 (4.0) | 230 (3.9) | 0.3006 | 235 (3.4) | 183 (3.9) | 314 (5.2) | < 0.0001 |
Proir MI, n (%) | 88 (1.5) | 84 (1.4) | 86 (1.5) | 0.9573 | 73 (1.1) | 67 (1.4) | 119 (2.0) | 0.0001 |
Proir CABG, n (%) | 10 (0.2) | 7 (0.1) | 1 (0.0) | 0.0313 | 7 (0.1) | 2 (0.0) | 9 (0.1) | 0.2212 |
Procedure_DES, n (%) | 5612 (95.0) | 5625 (95.4) | 5579 (95.3) | 0.4597 | 6506 (94.1) | 4538 (95.7) | 5774 (96.1) | < 0.0001 |
Procedure_BES, n (%) | 164 (2.8) | 134 (2.3) | 107 (1.8) | 0.0027 | 198 (2.9) | 105 (2.2) | 102 (1.7) | 0.0001 |
Procedure_CABG, n (%) | 2 (0.0) | 3 (0.1) | 1 (0.0) | 0.6098 | 1 (0.0) | 3 (0.1) | 2 (0.0) | 0.3726 |
Hemoglobin, g/L | 125.1 ± 19.2 | 136.2 ± 17.1 | 143.9 ± 16.1 | < 0.0001 | 136.7 ± 19.0 | 135.4 ± 17.4 | 132.9 ± 20.4 | < 0.0001 |
eGFR, mL/min/1.73 m2 | 68.6 (26.0) | 79.3 (22.7) | 85.1 (21.2) | < 0.0001 | 80.2 (22.5) | 77.6 (22.4) | 74.7 (27.4) | < 0.0001 |
LDL-C, mmol/L | 2.8 ± 1.0 | 3.1 ± 1.0 | 3.5 ± 1.2 | < 0.0001 | 3.2 ± 1.1 | 3.1 ± 1.0 | 3.1 ± 1.1 | < 0.0001 |
HDL-C, mmol/L | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.1 ± 0.3 | < 0.0001 | 1.1 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 | < 0.0001 |
TG, mmol/L | 1.4 ± 0.8 | 1.6 ± 1.1 | 2.0 ± 1.6 | < 0.0001 | 1.5 ± 1.1 | 1.6 ± 0.9 | 1.9 ± 1.5 | < 0.0001 |
hs-cTnT, ng/L | 1068.0 [203.5, 3112.8] | 438.2 [31.2, 1885.2] | 202.6 [12.7, 1134.8] | < 0.0001 | 405.6 [13.3, 2238.5] | 594.6 [61.2, 2327.2] | 601.5 [74.7, 2023.0] | < 0.0001 |
NT-proBNP, ng/L | 1985.0 [837.4, 4472.0] | 839.9 [347.9, 2090.5] | 544.1 [203.3, 1298.5] | < 0.0001 | 863.2 [318.0, 2313.0] | 904.6 [366.6, 2113.2] | 1167.0 [436.5, 3065.5] | < 0.0001 |
FPG, mmol/L | 7.5 ± 3.8 | 6.9 ± 3.1 | 6.9 ± 3.3 | 0.0002 | 5.4 ± 1.3 | 5.7 ± 1.3 | 9.0 ± 4.1 | < 0.0001 |
HbA1c, % | 6.7 ± 1.8 | 6.6 ± 1.7 | 6.6 ± 1.7 | 0.0308 | 5.3 ± 0.4 | 6.0 ± 0.2 | 8.0 ± 1.9 | < 0.0001 |
hs-CRP, mg/L | 36.0 ± 48.8 | 17.4 ± 31.8 | 11.8 ± 23.8 | < 0.0001 | 18.4 ± 35.2 | 20.9 ± 35.6 | 24.0 ± 39.8 | < 0.0001 |
FIB, g/L | 5.1 ± 1.8 | 4.2 ± 1.5 | 3.8 ± 1.3 | < 0.0001 | 4.1 ± 1.6 | 4.6 ± 1.7 | 4.6 ± 1.7 | < 0.0001 |
ALB, g/L | 32.1 ± 3.5 | 37.0 ± 2.8 | 41.0 ± 3.7 | < 0.0001 | 37.4 ± 5.0 | 36.2 ± 4.7 | 36.2 ± 5.0 | < 0.0001 |
PNI | 38.6 ± 3.3 | 45.4 ± 1.6 | 52.7 ± 4.0 | < 0.0001 | 46.0 ± 6.6 | 45.3 ± 6.4 | 45.2 ± 6.7 | < 0.0001 |
PLT, 109/L | 230.6 ± 81.7 | 239.1 ± 75.7 | 251.2 ± 69.2 | < 0.0001 | 237.9 ± 76.0 | 242.3 ± 74.7 | 241.4 ± 77.6 | 0.0037 |
NEU, 109/L | 7.7 ± 3.8 | 7.6 ± 3.6 | 7.9 ± 3.7 | 0.0002 | 8.0 ± 3.8 | 7.3 ± 3.5 | 7.8 ± 3.8 | < 0.0001 |
LYM, 109/L | 1.3 ± 0.5 | 1.7 ± 0.5 | 2.3 ± 0.8 | < 0.0001 | 1.7 ± 0.8 | 1.8 ± 0.8 | 1.8 ± 0.8 | < 0.0001 |
NLR | 7.4 (7.1) | 5.3 (4.0) | 3.9 (2.8) | < 0.0001 |  |  |  |  |
Left atrial, mm | 36.5 ± 5.2 | 35.6 ± 4.6 | 35.3 ± 4.5 | < 0.0001 | 35.3 ± 4.9 | 35.6 ± 4.7 | 36.8 ± 4.8 | < 0.0001 |
LVESD, mm | 35.3 ± 7.8 | 33.2 ± 6.7 | 32.4 ± 6.2 | < 0.0001 | 33.2 ± 6.8 | 33.7 ± 7.1 | 34.4 ± 7.3 | < 0.0001 |
LVEDD, mm | 50.1 ± 6.3 | 48.9 ± 5.6 | 48.5 ± 5.5 | < 0.0001 | 48.9 ± 5.7 | 49.2 ± 5.9 | 49.5 ± 6.0 | 0.0003 |
LVEF, % | 51.7 ± 11.6 | 56.0 ± 10.5 | 57.9 ± 9.6 | < 0.0001 | 56.1 ± 10.7 | 55.1 ± 10.5 | 54.0 ± 11.4 | < 0.0001 |
Beta-blockers, n (%) | 4400 (80.1) | 4621 (83.9) | 4575 (84.2) | < 0.0001 | 5076 (80.8) | 3798 (83.1) | 4723 (84.6) | < 0.0001 |
Statin, n (%) | 5297 (96.4) | 5365 (97.4) | 5318 (97.9) | < 0.0001 | 6127 (97.5) | 4462 (97.7) | 5392 (96.5) | 0.0005 |
CCB, n (%) | 967 (17.6) | 1103 (20.0) | 1132 (20.8) | 0.0001 | 925 (14.7) | 824 (18.0) | 1453 (26.0) | < 0.0001 |
ACEI or ARB, n (%) | 3837 (69.8) | 4039 (73.3) | 3861 (71.1) | 0.0002 | 4268 (67.9) | 3345 (73.2) | 4125 (73.9) | < 0.0001 |
Dual-antiplatelet therapy, n (%) | 5156 (93.8) | 5277 (95.8) | 5236 (96.4) | < 0.0001 | 5981 (95.2) | 4419 (96.7) | 5270 (94.4) | < 0.0001 |