Fig. 2
PCOS rats showed lower energy expenditure, while CRP KO rats showed increased energy expenditure in PCOS and HFD. CRP KO rats showed an increase in rectal temperature under DHEA-treated (a) or high-fat feeding (g) (*P < 0.05 vs. WT group; #P < 0.05 vs. DHEA-WT group). In metabolic cage studies, both 24 h VO2(b, c, h, i) and 24 h VCO2(d, j) were all significantly increased, while the RER ratios (e, f, k, l) were significantly decreased in CPR KO rats treated with DHEA or fed with HFD. (*P < 0.05 vs. WT group; #P < 0.05, ##P < 0.01 vs. CRP KO group, aP<0.05 vs. DHEA-WT group). Data are expressed as the mean ± SEM (n = 5 rats for each group)