Table 4 Pharmacokinetic variables of antidepressant drugs [126, 127]
From: Antidepressants and type 2 diabetes: highways to knowns and unknowns
Variables | The characteristics |
|---|---|
Bioavailability | Most of them have moderate to high bioavailability, with exception of mainserin, and lofepramine have low bioavailability. |
T1/2 life | Most of them have short half-life with exception of vortioxetine and fluoxetine have half-life > 50 hrs. |
Volume of distribution | Low |
Protein binding | High, both of levomilnacipran and milnacipran have low |
Excretion | Urine, and less by urine and feces |
Enzyme inhibitors | Fluoxetine and fluvoxamine are strong enzyme inhibitors, though other antidepressant drugs are none to mild enzyme inhibitors. |