Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population

Table 4 Threshold effect analysis of TyG index on all-cause and cardiovascular mortality in the total population and stratified by sex

	Adjusted HR (95% CI), P-value
	All participants		Males		Females
All-cause mortality
Fitting by the standard linear model	1.16 (0.98, 1.37)	0.092	1.32 (1.05, 1.67)	0.019	1.04 (0.81, 1.35)	0.744
Fitting by the two-piecewise linear model
Inflection point	8.5		8.5		8.5
TyG < 8.5	0.55 (0.34, 0.90)	0.016	0.59 (0.31, 1.13)	0.112	0.55 (0.26, 1.16)	0.116
TyG ≥ 8.5	1.39 (1.14, 1.70)	0.001	1.62 (1.24, 2.12)	0.001	1.24 (0.91, 1.70)	0.173
P for Log-likelihood ratio	0.002		0.011		0.044
Cardiovascular mortality
Fitting by the standard linear model	1.00 (0.67, 1.48)	0.989	1.25 (0.77, 2.02)	0.374	0.69 (0.34, 1.41)	0.311
Fitting by the two-piecewise linear model
Inflection point	8.7		8.7		8.7
TyG < 8.7	0.30 (0.14, 0.65)	0.002	0.28 (0.10, 0.76)	0.013	0.47 (0.12, 1.77)	0.263
TyG ≥ 8.7	1.82 (1.14, 2.92)	0.012	2.28 (1.32, 3.92)	0.003	0.93 (0.32, 2.75)	0.901
P for Log-likelihood ratio	< 0.001		0.002		0.045

Adjusted for survey cycle, age, sex (only for all participants), education, smoking, BMI, LDL-C, HDL-C, eGFR, diabetes, hypertension, CAD, cancer, statins, and glucose-lowering drugs

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