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Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: Therapeutic effects on the development of heart failure with preserved ejection fraction by the sodium-glucose cotransporter 2 inhibitor dapagliflozin in type 2 diabetes

Fig. 7

Proteomics deciphered the changes in the treated T2DM individuals with HFpEF. a Summary of differentially expressed proteins for each pairwise comparison. b Venn diagram showing the relationship between three pairwise comparisons. c Heatmap for protein detection from the proteomics data. Each column represents a protein marker, and each row represents a loading sample of the DM-HF and the DAPA group. d Volcano plots of the proteomics data for the pairwise comparison. Up-regulated and down-regulated proteins are marked with red and blue colors, respectively. e KEGG pathway enrichment and f GO term analyses. g The interaction relationship of differentially expressed proteins was obtained from the STRING database (https://string-db.org/), and the top 25 proteins were selected to draw the interaction network diagram. Red represents up-regulated genes, and the green represents down-regulated genes. The size of the circle represents the degree of connectivity

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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