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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: Therapeutic effects on the development of heart failure with preserved ejection fraction by the sodium-glucose cotransporter 2 inhibitor dapagliflozin in type 2 diabetes

Fig. 4

Dapagliflozin alleviated myocardial nitro-oxidative stress and inflammatory response. Real-time PCR measurements of a–c PLB and SERCA2a, d Thioredoxin-1, and e Catalase in the myocardium. f Serum 3-NT levels in the experimental groups. g–i The activity of classical antioxidants and j content of cardiac MDA. (k) Representative western blot bands of myocardial p-P65, P65, and IκBα levels. l, m Densitometric semi-quantitative determination of protein expression levels using ImageJ. n Gene expression of classic pro-inflammatory cytokines. Values are expressed as the mean ± SD. n = 8 per group. *P < 0.05, **P < 0.01 vs. Lean; #P < 0.05 vs. ZDF

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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