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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Therapeutic effects on the development of heart failure with preserved ejection fraction by the sodium-glucose cotransporter 2 inhibitor dapagliflozin in type 2 diabetes

Fig. 3

The effects of dapagliflozin on myocardium fibrosis in diabetic rats. a Representative images of Masson's trichrome and PicroSirius staining. Bar = 200 and 100 μm, respectively. Magnification = ×20. b, c Fibrotic area quantification of stained sections. d Correlation analysis between PicroSirius positive area and the slope of EDPVR. e–g Quantitative real-time PCR was conducted to detect the mRNA expression of Fibronectin-1, Collagen-1, and TGF-β in the myocardium. Values are expressed as the mean ± SD. n = 8 per group. *P < 0.05, **P < 0.01 vs. Lean; #P < 0.05 vs. ZDF

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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