Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes

Table 1 The clinical characteristic of individuals in 2017–2018 NHANES

Variables	Non-diabetes	Diabetes	P
n	2048	363
Gender
Male	917 (81.9%)	203 (18.1%)	< 0.001
Female	1131 (87.6%)	160 (12.4%)	< 0.001
Age(years)	42.55 ± 20.71	63.54 ± 12.41	< 0.001
BMI(kg/m²)	28.61 ± 7.42	32.24 ± 7.74	< 0.001
SBP(mmHg)	121.77 ± 19.31	133.60 ± 20.69	< 0.001
DBP(mmHg)	70.55 ± 13.06	69.91 ± 14.36	0.418
TC(mmol/L)	4.71 ± 1.04	4.45 ± 1.16	< 0.001
TG(mmol/L)	1.07 ± 0.67	1.47 ± 0.72	< 0.001
HDL(mmol/L)	1.40 ± 0.38	1.27 ± 0.35	< 0.001
LDL(mmol/L)	2.81 ± 0.91	2.51 ± 1.01	< 0.001
FPG(mmol/L)	5.74 ± 1.05	8.82 ± 3.23	< 0.001
Fins(uU/mL)*	2.31 ± 0.71	2.66 ± 0.89	< 0.001
HOMAB	93.76 (61.79 ~ 148.58)	61.80 (33.81 ~ 108.32)	< 0.001
Race
Mexican American	285 (80.1%)	71 (19.9%)	0.098
Other hispanic	185 (83.3%)	37 (16.7%)
Non-hispanic white	698 (85.7%)	116 (14.3%)
Non-hispanic black	490 (86.7%)	75 (13.3%)
Non-hispanic Asian	263 (85.7%)	44 (14.3%)
Other race	127 (86.4%)	20 (13.6%)
Smoking status
Yes	662 (77.5%)	192 (22.5%)	< 0.001
No	1085 (86.5%)	170 (13.5%)	< 0.001
Alcohol consumption
Yes	1456 (82.4%)	311 (17.6%)	0.117
No	177 (86.8%)	27 (13.2%)	0.117

^*The variable was transferred by ln
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglyceride, LDL lower density lipoprotein, HDL higher density lipoprotein, FPG fasting plasma glucose, Fins fasting insulin, HOMAB Homeostasis model assessment β cell function; Smoking status: whether the participants smoked at least 100 cigarettes in life (Yes/No). Alcohol consumption: whether the interviewee ever had a drink of any kind of alcohol. We compared clinical characteristics and iron indices between the diabetes and non-diabetes groups using a two-sample t-test for variables with normal distribution, χ2 test for variables with count data, and a non-parametric test for variables with non-normal distribution

ISSN: 1758-5996