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Table 1 Characteristics of GWAS datasets in this study

From: Type 2 diabetes has a protective causal association with thoracic aortic aneurysm: a Mendelian randomization study

Contribution

Traits

Sample size

Population

References

Exposures

T2D

Cases: 62892/Controls: 596424

European

Xue et al

T2D

Cases: 12171/Controls: 56862

European

Morris et al

HbA1c

46368

European

Soranzo et al

FG

200622

European

Chen et al

FI

151013

European

Chen et al

Outcomes

TAA

Cases: 7321/Controls: 317899

European

FinnGen r8

AAoD

38694

European

Pirruccello et al

DAoD

39688

European

Pirruccello et al

  1. T2D type 2 diabetes, HbA1c glycated hemoglobin, FG fasting glucose, FI fasting insulin, TAA thoracic aortic aneurysm, AAoD ascending aortic diameter, DAoD descending aortic diameter