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Table 1 Characteristics of the subjects

From: Higher β cell death in pregnant women, measured by DNA methylation patterns of cell-free DNA, compared to new-onset type 1 and type 2 diabetes subjects: a cross-sectional study

 

Control

N = 10

GDM

N = 25

NON-GDM

N = 25

T1D

N = 16

T2D

N = 18

p

Age(years)

36.30 ± 7.7a

35.16 ± 4.01a

33.19 ± 4.38a

30.44 ± 14.21a

44.94 ± 13.21b

 < 0.001

Sex(%)(M/F)

23/77

0/100

0/100

31.3/68.7

76.5/23.5

NA

Weight (Kg)

64.1 ± 13.5a.b

79.61 ± 15.7c

75.3 ± 17.3b.c

57.7 ± 11.1a

94.98 ± 20.23d

 < 0.001

Fasting glucose (mg/dl)*

83.87 ± 9.9a

84.2 ± 10.9a

83.46 ± 7.64a

252 ± 107.3b

264.12 ± 83.41b

 < 0.001

BMI

22.7 ± 3.9a

30.1 ± 5.1b

30.1 ± 5.4b

21.5 ± 5.0a

31.9 ± 7.2b

 < 0.001

HbA1c

5.3 ± 0.3a

5.1 ± 0.3a

13.7 ± 4.4b

14.0 ± 4.7b

 

c-Peptide

4.2 ± 4.5a

1.4 ± 0.3b

0.52 ± 0.3b

1.6 ± 1.0b

 

GAD positive (%)

   

56.3

0

 < 0.001

IA2 positive(n/%)

   

43.8

0

 < 0.001

Newborn weight (gr)

 

3.097 ± 0.345

3.277 ± 0.382

  

NS

HOMA-IR

 

2.9 ± 2.3

1.6 ± 0.9

  

0.045

  1. Data are expressed as mean ± SD or percentages. Mean values were compared by one way ANOVA test. Post hoc analysis was done by Duncan test. Different letters indicate statistically significant differences between groups. *Fasting glucose was measured for all the participants except for T1D and T2D patients who attended to the clinic without an appointment