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Table 4 Associations between between nocturnal TIR and albuminuria

From: Differential correlation between time in range and eGFR or albuminuria in type 2 diabetes

 

Microalbuminuria

Macroalbuminuria

Any Albuminuria

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

Model 1

      

Nocturnal TIR

0.992(0.985–0.998)

0.015

0.984(0.974–0.994)

0.002

0.990(0.984–0.996)

0.002

Model 2

      

Nocturnal TIR

0.992(0.985–0.999)

0.027

0.992(0.985–0.999)

0.027

0.991(0.984–0.997)

0.002

SD

1.068(0.931–1.225)

0.348

1.068(0.931–1.225)

0.348

1.087(0.956–1.236)

0.002

Model 3

      

Nocturnal TIR

0.99(0.983–0.997)

0.005

0.983(0.972–0.993)

0.002

0.988(0.982–0.995)

0.001

MAGE

0.928(0.842–1.024)

0.137

0.954(0.827–1.101)

0.522

0.935(0.856–1.022)

0.139

Model 4

      

Nocturnal TIR

0.992(0.985–0.999)

0.018

0.984(0.973–0.994)

0.002

0.99(0.983–0.996)

0.001

CV

0.72(0.1-5.183)

0.744

13.837(1.455-131.599)

0.022

2.392(0.487–11.761)

0.283

Model 5

      

Nocturnal TIR

0.988(0.98–0.996)

0.003

0.984(0.972–0.996)

0.007

0.987(0.98–0.995)

0.001

ADDR

0.981(0.963–0.999)

0.04

0.998(0.975–1.021)

0.867

0.987(0.972–1.003)

0.109

Model 6

      

Nocturnal TIR

0.992(0.985-1)

0.051

0.986(0.975–0.997)

0.012

0.991(0.985–0.998)

0.015

M-value

1.003(0.991–1.014)

0.648

1.008(0.998–1.018)

0.128

1.005(0.997–1.014)

0.234

  1. a TIR: time in range; Nocturnal TIR: nocturnal time in range; HbA1C: hemoglobin A1C; SD:standard deviation; MAGE: mean amplitude of glucose excursions; CV: coefficient of variation; ADDR: average daily risk range; CI: confidence interval; eGFR: estimated glomerular filtration rate
  2. b Model 1 was adjusted for age, diabetes duration, sex, BMI, lipid profile, blood pressure, and HbA1c (%); model 2 was adjusted for variables as in model 1 and for SD; model 3 was adjusted for variables as in model 1 and for MAGE; model 4 was adjusted for variables as in model 1 and for CV; model 5 was adjusted for variables as in model 1 and for ADDR; model 6 was adjusted for variables as in model 1 and for M-value