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Table 3 Associations between between TIR and albuminuria

From: Differential correlation between time in range and eGFR or albuminuria in type 2 diabetes

 

Microalbuminuria

Macroalbuminuria

Any Albuminuria

 

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

Model 1

      

TIR

0.993(0.985-1.000)

0.062

0.988(0.976-1.000)

0.053

0.992(0.985–0.999)

0.026

Model 2

      

TIR

0.994(0.986–1.002)

0.126

0.99(0.977–1.002)

0.112

0.993(0.986–1.001)

0.082

SD

1.069(0.926–1.233)

0.363

1.113(0.941–1.316)

0.213

1.091(0.955–1.247)

0.2

Model 3

      

TIR

0.989(0.981–0.997)

0.008

0.987(0.974-1)

0.052

0.989(0.981–0.996)

0.004

MAGE

0.91(0.821–1.008)

0.072

0.948(0.816–1.101)

0.484

0.92(0.838–1.01)

0.079

Model 4

      

TIR

0.993(0.985-1)

0.065

0.987(0.975-1)

0.05

0.992(0.985–0.999)

0.026

CV

0.626(0.086–4.558)

0.644

13.67(1.45-128.892)

0.022

2.168(0.437–10.764)

0.344

Model 5

      

TIR

0.983(0.973–0.994)

0.003

0.988(0.973–1.003)

0.118

0.986(0.977–0.996)

0.006

ADDR

0.972(0.95–0.994)

0.014

1(0.975–1.025)

0.989

0.983(0.965–1.002)

0.078

Model 6

      

TIR

0.994(0.985–1.003)

0.216

0.992(0.979–1.005)

0.224

0.995(0.986–1.003)

0.197

M-value

1.005(0.992–1.017)

0.482

1.01(0.998–1.022)

0.105

1.007(0.997–1.018)

0.164

  1. a TIR: time in range; HbA1C: hemoglobin A1C; SD: standard deviation; MAGE: mean amplitude of glucose excursions; CV: coefficient of variation; ADDR: average daily risk range; CI: confidence interval
  2. b Model 1 was adjusted for age, diabetes duration, sex, BMI, lipid profile, blood pressure, and HbA1c (%); model 2 was adjusted for variables as in model 1 and for SD; model 3 was adjusted for variables as in model 1 and for MAGE; model 4 was adjusted for variables as in model 1 and for CV; model 5 was adjusted for variables as in model 1 and for ADDR; model 6 was adjusted for variables as in model 1 and for M-value