The association and prediction value of acylcarnitine on diabetic nephropathy in Chinese patients with type 2 diabetes mellitus

Table 2 Factor and their loadings derived by 25 acylcarnitine metabolites

Variables	Factor1	Factor2	Factor3	Factor4	Factor5	Factor6
C2	0.50429	0.34748	0.14162	0.68981	0.10081	-0.02151
C3	0.08067	0.53851	0.21331	0.19845	0.45228	-0.09907
C4	0.59019	0.251	0.03502	0.53335	0.33466	-0.08973
C4-OH	0.07685	0.00693	0.07368	0.82499	0.00633	0.24523
C4DC	0.15497	0.01182	0.36127	-0.08586	0.55835	-0.07317
C5	0.25588	0.22914	0.10886	0.48798	0.5693	0.03655
C5-OH	0.02242	0.14218	0.1133	-0.01669	0.70797	0.33312
C5DC	0.79163	0.07983	0.16201	0.30658	0.05912	0.00873
C5:1	0.31919	0.17655	-0.00946	0.29204	0.48242	0.11599
C6	0.8317	0.16068	0.05042	0.30218	0.13862	0.02847
C8	0.93584	0.10313	0.05502	0.0886	0.08998	0.01758
C10	0.89856	0.09134	0.06551	-0.0812	0.09491	0.13032
C12	0.73262	0.20815	-0.01328	-0.09524	0.15774	0.44017
C14	0.43019	0.46226	-0.10485	0.00559	0.21252	0.51255
C14-OH	0.45857	0.09468	0.05866	0.18343	0.10609	0.46761
C14DC	0.40245	0.28539	0.55178	0.33555	0.00955	-0.047
C14:1	0.80376	0.19505	0.11113	0.11034	0.07487	0.14416
C16	0.2405	0.83777	0.06037	0.06701	0.13985	0.1017
C16-OH	0.08469	0.2005	0.18094	0.15398	0.07779	0.69627
C16:1-OH	0.14883	0.68625	0.31955	0.06626	0.08016	0.15477
C18	0.16894	0.83086	0.17011	0.08513	0.14699	0.15219
C20	0.07642	0.48323	0.32206	0.11856	-0.02242	0.16375
C22	-0.01123	0.2058	0.69597	0.32022	0.01519	0.21193
C24	0.09035	0.1236	0.78191	-0.03713	0.18574	0.16162
C26	0.03762	0.23012	0.76184	-0.04315	0.20975	-0.09637

C2, acetylcarnitine; C3, propionylcarnitine; C4, butyrylcarnitine; C4-OH, hydroxylbutyrylcarnitine; C4DC, succinylcarnitine; C5, isovalerylcarnitine; C5-OH, 3-hydroxyisovalerylcarnitine; C5DC, glutarylcarnitine; C5:1, tiglylcarnitine; C6, hexanoylcarnitine; C8, octanoylcarnitine; C10, decanoylcarnitine; C12, lauroylcarnitine; C14, myristoylcarnitine; C14-OH, 3-hydroxyl-tetradecanoylcarnitine; C14DC, tetradecanoyldiacylcarnitine; C14:1, tetradecenoylcarnitine; C16, palmitoylcarnitine; C16-OH, 3-hydroxypalmitoylcarnitine; C16:1-OH, 3-hydroxypalmitoleylcarnitine; C18, octadecanoylcarnitine; C20, arachidic carnitine; C22, behenic carnitine; C24, tetracosanoic carnitine; C26, hexacosanoic carnitine
The factors were extracted from 25 acylcarnitine according to eigenvalue > 1, scree plot, and cumulative variance by principal component analysis. Varimax rotation was used to maximize the variance difference of each factor, so as to better explain the factors. Each black-marked acylcarnitine in each column is classified as a factor in the corresponding column

ISSN: 1758-5996