Table 3 Proportion of association of non-traditional CVRF with MetS mediated by BMI

Binary scale, HUA (vs. Non-HUA)

 Total Effect (OR)

1.609(1.295–1.923)

< 0.001

2.030(1.530–2.530)

< 0.001

 Natural Direct Effect (OR)

1.324(1.079–1.569)

0.010

1.578(1.209–1.948)

0.002

 Natural Indirect Effect (OR)

1.215(1.137–1.294)

< 0.001

1.287(1.183–1.391)

< 0.001

 Percentage Mediated (%)

46.80(29.80–63.79)

< 0.001

43.89(30.38–57.40)

< 0.001

Continuous scale, Per SD in UA

 Total Effect (OR)

1.274(1.187–1.361)

< 0.001

1.485(1.352–1.618)

< 0.001

 Natural Direct Effect (OR)

1.127(1.053–1.200)

< 0.001

1.268(1.159–1.377)

< 0.001

 Natural Indirect Effect (OR)

1.131(1.103–1.159)

< 0.001

1.171(1.133–1.210)

< 0.001

 Percentage Mediated (%)

53.76(39.56–67.96)

< 0.001

44.77(34.71–54.84)

< 0.001

Binary scale, HHCY (vs. Non-HHCY)

 Total Effect (OR)

1.023(0.885–1.160)

0.747

1.339(1.101–1.577)

0.005

 Natural Direct Effect (OR)

0.975(0.851–1.099)

0.688

1.212(1.008–1.416)

0.042

 Natural Indirect Effect (OR)

1.049(1.003–1.096)

0.038

1.104(1.041–1.168)

0.001

 Percentage Mediated (%)

211.93(-997.27–1421.13)

0.731

37.34(13.86–60.83)

0.002

Continuous scale, Per SD in Ln HCY

 Total Effect (OR)

0.976(0.911–1.042)

0.479

1.082(0.984–1.179)

0.100

 Natural Direct Effect (OR)

0.959(0.898–1.020)

0.191

1.042(0.953–1.131)

0.354

 Natural Indirect Effect (OR)

1.018(0.995–1.040)

0.125

1.038(1.008–1.069)

0.015

 Percentage Mediated (%)

-71.78(-319.92–176.36)

0.571

48.58(-6.03–103.20)

0.081

Binary scale, HHsCRP (vs. Non-HHsCRP)

 Total Effect (OR)

1.497(1.218–1.776)

0.0005

1.560(1.210–1.909)

0.002

 Natural Direct Effect (OR)

1.318(1.085–1.552)

0.0076

1.386(1.090–1.682)

0.011

 Natural Indirect Effect (OR)

1.136(1.069–1.203)

< 0.001

1.125(1.047–1.203)

0.002

 Percentage Mediated (%)

36.02(18.78–53.25)

< 0.001

30.99(13.16–48.83)

0.001

Continuous scale, Per SD in Ln HsCRP

 Total Effect (OR)

1.360(1.266–1.455)

< 0.001

1.349(1.237–1.461)

< 0.001

 Natural Direct Effect (OR)

1.213(1.132–1.293)

< 0.001

1.205(1.109–1.301)

< 0.001

 Natural Indirect Effect (OR)

1.122(1.095–1.149)

< 0.001

1.120(1.088–1.152)

< 0.001

 Percentage Mediated (%)

40.93(31.40–50.46)

< 0.001

41.34(29.58–53.09)

< 0.001