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Table 1 Dynamic changes of left ventricular function in diabetic mice

From: Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging

 

Body weight (g)

FBG (mmol/L)

LVEF

(%)

E/e’

Control (n = 8)

25.7 ± 2.3

7.0 ± 2.0

73.5 ± 3.3

17.3 ± 3.2

8w (n = 4)

45.9 ± 3.8

14.8 ± 1.5

70.0 ± 1.4

19.8 ± 2.6

a P

< 0.001*

0.008*

0.101

0.184

12w (n = 4)

50.1 ± 4.3

25.1 ± 4.7

70.8 ± 5.4

21.2 ± 1.9

a P

< 0.001*

< 0.001*

0.191

0.040*

b P

< 0.012#

0.003#

0.752

0.482

16w (n = 4)

51.7 ± 5.1

25.9 ± 4.3

64.3 ± 2.2

24.5 ± 4.3

a P

< 0.001*

< 0.001*

< 0.001*

0.001*

b P

0.003#

0.002#

0.024#

0.036#

c P

0.346

0.795

0.012&

0.142

20w (n = 4)

47.8 ± 4.2

25.7 ± 8.0

60.8 ± 2.8

24.5 ± 1.4

a P

< 0.001*

< 0.001*

< 0.001*

0.001*

b P

0.410

0.002#

0.001#

0.035#

c P

0.273

0.852

< 0.001&

0.137

d P

0.098

0.942

0.151

0.984

  1. Note:
  2. 1. FBG: fasting blood glucose; LVEF: left ventricular ejection fraction; E/e’: the ratio of early diastolic transmitral flow velocity to early diastolic mitral annular tissue velocity
  3. 2. aP: P value compared to Control; bP: P value compared to 8w; cP: P value compared to 12w; dP: P value compared to 16w; the differences are significant (P < 0.05) when compared with control group (*), 8w group (#), and 12w group (&)