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Table 1 Comparison of baseline characteristics of patients with MAFLD with and without CAD

From: Fibrosis score 4 index has an independent relationship with coronary artery diseases in patients with metabolic-associated fatty liver disease

 

Non-CAD

N = 1280

CAD

N = 364

P-Value

Age, years

53.02 ± 11.02

62.10 ± 10.18

< 0.001

Duration of DM, years

8.87 ± 6.69

14.97 ± 8.79

< 0.001

Gender (female/male)

51.5% (659) /48.5% (621)

38.5% (140) / 61.5% (224)

< 0.001

Waist circumference, cm

103.36 ± 11.09

103.72 ± 10.02

0.55

Waist/Hip

0.94 ± 0.05

0.95 ± 0.05

0.01

SBP, mmHg

128.62 ± 33.68

133.00 ± 16.98

0.017

DBP, mmHg

79.75 ± 7.78

79.68 ± 8.81

0.90

HTN

34.7% (443)

58.5% (213)

< 0.001

BMI, kg/m²

31.36 ± 5.63

31.06 ± 5.14

0.37

platelet

275 ± 52.7

260 ± 59.80

< 0.001

FBS, mg/dl

155.55 ± 52.25

169.82 ± 67.06

< 0.001

2hpp, mg/dl

211.98 ± 83.58

231.28 ± 83.71

< 0.001

Hb AIC, %

7.591 ± 1.61

7.80 ± 1.45

0.01

Cholesterol, mg/dl

186.20 ± 43.95

168.33 ± 43.46

< 0.001

HDL-C, mg/dl

44.40 ± 11.73

43.92 ± 11.16

0.48

LDL-C, mg/dl

105.91 ± 34.22

91.32 ± 32.86

< 0.001

TG, mg/dl

195.86 ± 141.84

169.39 ± 83.77

< 0.001

Creatinine

0.97 ± 0.23

1.04 ± 0.23

< 0.001

AST, U/L

29.29 ± 17.83

26.85 ± 14.92

0.010

ALT, U/L

41.07 ± 23.43

36.58 ± 24.29

0.002

ALKP, U/L

169.77 ± 88.35

153.34 ± 72.30

0.005

eGFR,mL/min/1.73 m²

103.96 ± 31.62

95.98 ± 27.25

< 0.001

Albuminuria

17.3% (134)

28.4% (74)

< 0.001

HOMA-IR

4.05 (2.72–5.87)

4 (2.80–5.65)

0.44

Smoking % (n)

4.6% (59)

6% (21)

0.43

FIB4

0.94 ± 0.47

1.15 ± 0.48

< 0.001

Insulin levels

12.57 ± 7.53

11.36 ± 5.97

0.003

Statin use

Antidiabetic drugs

56.2%

74.1%

< 0.001

Oral agents

84.3%

84.1%

0.50

Oral agents + Insulin

12.7%

11.6%

 

Insulin

2.9%

4.3%

 
  1. Data are presented as mean ± standard deviation, median (interquartile range), or counts (percentages).MAFLD: metabolic-associated fatty liver disease, DM: diabetes mellitus, SBP: systolic blood pressure, DBP: diastolic blood pressure, BMI: body mass index, FBS: fasting blood glucose, HBA1C: hemoglobin A1C, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein cholesterol, TG: triglyceride, AST: aspartate transaminase, ALT: alanine transaminase, ALP: alkaline phosphatase, eGFR: estimated Glomerular Filtration Rate, HOMA-IR: homeostatic model assessment of insulin resistance