Fig. 1

Comparison of various metabolic indices in the three groups of mice. A Long-term and regular high-fat diet led to weight gain in group H and S mice. The weight of mice in group S decreased significantly after semaglutide treatment. Comparison of FPG (B), TC (C), TG (D), LDL-C (E) and HDL-C (F) levels in mice among the three groups at the end of 24 weeks; ^*p < 0.05 and ^**p < 0.01 vs. C; ^#p < 0.05 and ^##p < 0.01 vs. H