Association of prognostic nutritional index level and diabetes status with the prognosis of coronary artery disease: a cohort study

Li, Tianyu; Yuan, Deshan; Wang, Peizhi; Zeng, Guyu; Jia, Sida; Zhang, Ce; Zhu, Pei; Song, Ying; Tang, Xiaofang; Gao, Runlin; Xu, Bo; Yuan, Jinqing

doi:10.1186/s13098-023-01019-8

Table 4 Model performance after adding nutrition indexes to the GRACE risk score for predicting all-cause death

From: Association of prognostic nutritional index level and diabetes status with the prognosis of coronary artery disease: a cohort study

	AUC (95% CI)	p	NRI (95% CI)	p	IDI (95% CI)	p
All participants
GRACE	0.688 (0.651, 0.725)	–	Reference	–	Reference	–
GRACE+PNI category^a	0.733 (0.698, 0.768)	<0.001	0.323 (0.186, 0.466)	<0.001	0.080 (0.023, 0.137)	0.006
GRACE+dichotomous PNI^b	0.730 (0.695, 0.765)	<0.001	0.221 (− 0.176, 0.350)	0.819	0.088 (0.032, 0.144)	0.002
GRACE+continuous PNI^c	0.733 (0.698, 0.768)	<0.001	0.102 (− 0.041, 0.262)	0.326	0.094 (0.037, 0.151)	0.001
GRACE+postprocedural PNI^d	0.731 (0.694, 0.768)	<0.001	0.202 (− 0.203, 0.340)	0.142	0.075 (0.014, 0.136)	0.015
GRACE+ΔPNI^e	0.694 (0.656, 0.733)	0.119	0.079 (− 0.048, 0.230)	0.449	1x10^-4 (-0.044, 0.044)	0.998
GRACE+GLIM^f	0.706 (0.670, 0.743)	0.026	− 0.128 (− 0.326, 0.201)	0.318	0.024 (− 0.027, 0.074)	0.363
Diabetic patients
GRACE	0.707 (0.657, 0.756)	–	Reference	–	Reference	–
GRACE+PNI category^a	0.763 (0.713, 0.813)	<0.001	0.414 (0.179, 0.628)	<0.001	0.089 (0.023, 0.154)	0.008
GRACE+dichotomous PNI^b	0.762 (0.713, 0.811)	<0.001	0.346 (0.129, 0.528)	<0.001	0.091 (0.018, 0.164)	0.015
GRACE+continuous PNI^c	0.766 (0.718, 0.815)	<0.001	0.228 (0.018, 0.441)	0.019	0.104 (0.031, 0.178)	0.005
GRACE+postprocedural PNI^d	0.746 (0.692, 0.800)	0.003	0.240 (− 0.236, 0.404)	0.349	0.055 (-0.010, 0.120)	0.097
GRACE+ΔPNI^e	0.704 (0.652, 0.755)	0.310	0.147 (− 0.067, 0.375)	0.493	− 0.019 (− 0.073, 0.035)	0.495
GRACE+GLIM^f	0.741 (0.692,0.790)	0.009	− 0.267 (− 0.394, 0.421)	0.288	0.08 (0.005, 0.149)	0.036
Nondiabetic patients
GRACE	0.662 (0.608, 0.716)	–	Reference	–	Reference	–
GRACE+PNI category^a	0.716 (0.667, 0.764)	0.001	0.261 (0.118, 0.449)	0.016	0.104 (0.019, 0.188)	0.017
GRACE+dichotomous PNI^b	0.714 (0.665, 0.762)	0.002	− 0.104 (-0.161, 0.294)	0.543	0.090 (0.006, 0.173)	0.036
GRACE+continuous PNI^c	0.713 (0.665, 0.762)	0.002	− 0.007 (-0.117, 0.266)	0.607	0.103 (0.020, 0.187)	0.015
GRACE+postprocedural PNI^d	0.725 (0.674, 0.775)	0.002	− 0.179 (-0.198, 0.369)	0.416	0.045 (− 0.017, 0.160)	0.112
GRACE+ΔPNI^e	0.675 (0.617, 0.732)	0.133	0.037 (− 0.095, 0.242)	0.562	− 3x10^-4 (-0.002, 0.002)	0.706
GRACE+GLIM^f	0.678 (0.626, 0.731)	0.243	− 0.131 (− 0.241, 0.270)	0.352	0.025 (− 0.052, 0.101)	0.527

^aPreprocedural PNI categorized by the optimal cut-off value for all-cause death of 48.49
^bPreprocedural PNI grouped by the median
^cPreprocedural PNI analyzed as a continuous variable
^dPostprocedural PNI categorized by 48.49
^eA continuous variable calculated as postprocedural PNI minus preprocedural PNI
^fMalnutrition defined by the GLIM criteria
AUC: area under the curve, CI confidence interval, GLIM Global Leadership Initiative on Malnutrition, GRACE global register acute coronary events, IDI integrated discrimination improvement, NRI net reclassification improvement, PNI prognostic nutritional index

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