Proteomics of high-density lipoprotein subfractions and subclinical atherosclerosis in type 1 diabetes mellitus: a case–control study

Table 3 Correlation between vascular function and HDL₂ and HDL₃ proteomics in subjects with T1D and controls

	PWV		FMD after reactive hyperemia		FMD after nitrate
	HDL₂	HDL₃	HDL₂	HDL₃	HDL₂	HDL₃
T1D
A1AT		− 0.38 (0.04)			− 0.47 (0.01)
A1BG	0.49 (< 0.01)
ApoA-I		− 0.38 (0.04)	0.41 (0.02)
ApoA-II	0.49 (< 0.01)
ApoA-IV					− 0.40 (0.04)
ApoB	0.41 (0.03)
ApoE		− 0.40 (0.03)
ApoF					− 0.44 (0.02)
ApoL-I	− 0.60 (< 0.01)	− 0.44 (0.02)
C3		− 0.48 (0.01)
CLU	− 0.39 (0.04)	− 0.51 (< 0.01)			− 0.39 (0.04)
HBB		− 0.38 (0.04)
GPLD1				− 0.42 (0.02)
IGFALS		− 0.47 (0.01)			0.43 (0.03)
LCAT		− 0.49 (< 0.01)
Lp(a)	0.46 (0.01)
PCSK9	0.51 (< 0.01)				− 0.43 (0.03)
PCYOX			0.36 (0.05)
PON1		− 0.47 (0.01)
SAA4	0.43 (0.02)
VTN					− 0.39 (0.04)
Controls
ApoC- IV		− 0.36 (0.05)
CETP		0.38 (0.04)		− 0.37 (0.05)
HBB	− 0.38 (0.04)
Orm1	− 0.39 (0.03)
RBP4		0.38 (0.04)

Spearman’s correlation, expressed as a correlation coefficient (r) and the significance of the correlation is expressed as a p value, in parentheses. A1AT alpha-1 antitrypsin, A1BG A1BG alpha-1-B glycoprotein, Apo apolipoprotein, C3 complement C3, CETP cholesteryl ester transfer protein, CLU clusterin or apolipoprotein J, FMD flow-mediated vasodilation, GPLD1 phosphatidylinositol-glycan-specific phospholipase D, HBB hemoglobin subunit beta, IGFALS acid-labile subunit, LCAT lecithin cholesterol acyltransferase, Lp(a) apolipoprotein(a), Orm1 alpha-1 glycoprotein 1 or orosomucoid, PCSK9 proprotein convertase subtilisin/kexin type 9, PCYOX prenylcysteine oxidase 1, PON1 paraoxonase-1, PWV pulse wave velocity, RBP4 retinol binding protein type 4, SAA4 serum amyloid A type 4, T1D type 1 diabetes, VTN vitronectin

ISSN: 1758-5996