Skip to main content

Table 1 Clinical, antropometric data and vascular function from subjects with type 1 diabetes and controls

From: Proteomics of high-density lipoprotein subfractions and subclinical atherosclerosis in type 1 diabetes mellitus: a case–control study

 

T1D

n = 50

Controls

n = 30

p

Female sex (%)

50

50

Age (years)

34 (29–40)

34 (30–46)

0.474

BMI (kg/m2)

22.9 (20.3–26.6)

24.4 (23.2–26.60)

0.077

Abdominal circumference (cm)

89 (80–96)

86 (79–95)

0.530

Time of T1D (years)

22 (16 – 30)

NA

 

Age at T1D diagnosis (years)

11.5 (6 – 18)

NA

 

Hypertension, n (%)

15 (30%)

0

 

HbA1c (%)

8.3 (6.9–9.3)

5.4 (5.0–5.5)

 < 0.001

Fructosamine (µmol/L)

362 (336–421)

226 (215–237)

 < 0.001

TC (mg/dL)

163 (145–184)

186.5 (153–199)

0.017

HDLc (mg/dL)

57 (48–67)

56.5 (46–68)

0.709

LDLc (mg/dL)

86.5 (75–104)

97 (86–120)

0.021

TG (mg/dL)

69 (57–93)

86 (68–134)

0.036

eGFR (mL/min/1.73m2)

103.5 (90.2–117.2)

101.0 (89.7–100.1)

0.538

Albuminuria (mg/g creatinine)

6.1 (4.2–16.4)

NA

 

Retinopathy. n (%)

24 (48%)

  

Albuminuria. n (%)

   

 A1: < 30 mg/g creatinine

40 (80%)

  

 A2: 30–300 mg/g creatinine

8 (16%)

  

 A3: > 300 mg/g creatinine

2 (4%)

  

Stages of kidney function—eGFR (mL/min/1.73m2)

   

 G1: ≥ 90

38 (76%)

  

 G2: 60–89

8 (16%)

  

 G3a: 45–59

2 (4%)

  

 G3b: 30–44

1 (2%)

  

 G4: 15–29

0

  

 G5: < 15

1 (2%)

  

Peripheral neuropathy, n (%)

6 (12%)

  

CAN, n (%)

15 (30%)

  

Medications, n (%)

   

Statins

20 (40%)

  

 Atorvastatin

10 (20%)

  

 Simvastatin

10 (20%)

  

ACEi

12 (24%)

  

ARB

7 (14%)

  

Thiazide Diuretics

7 (14%)

  

Spironolactone

1 (2%)

  

Beta blocker

2 (4%)

  

CCB

1 (2%)

  

Hydralazine

1 (2%)

  

Ten-year ASCVDR estimate (%)

   

 Steno T1 Engine

6.9 (4.2–15.6)

  

 QRISK3

4.5 (2.0–7.6)

  
 

n = 30

n = 30

 

PWV (m/s)

7.7 (6.9—8.4)

6.7 (6.1–7.3)

0.008

Brachial artery diameter (mm)

3.8 (3.2–4.3)

3.7 (3.3–4.5)

0.781

FMD after RH (%)

2.7 (− 0.1 to 8.6)

7.4 (2.7–9.7)

0.047

FMD after nitrate (%)

18.4 (14.1–4.6)

 
  1. Categorical variables: Absolute (n) and relative (%) frequency, Pearson’s Chi-square test. Continuous variables: Median (25th-75th percentile), Mann Whitney Test
  2. ACEi angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blocker, ASCVDR atherosclerotic cardiovascular disease risk, BMI body mass index, CAN cardiovascular autonomic neuropathy, CCB calcium channel blockers, eGFR estimated glomerular filtration rate, FMD flow-mediated vasodilation, HDLc HDL cholesterol, LDLc LDL cholesterol, NA not available, PWV pulse wave velocity, RH reactive hyperemia, T1D: type 1 diabetes, TG triglycerides, TC total cholesterol