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Table 3 Threshold effect analysis of SUA on all-cause, CVD, and cancer mortality

From: Association between serum uric acid levels and long-term mortality of metabolic dysfunction-associated fatty liver disease: a nationwide cohort study

Threshold (mg/dL)

HR (95% CI)

Univariate

Age-adjusted

Multivariatea

Male

 All-cause mortality

  ≤ 6.7

0.77 (0.65–0.92)

0.86 (0.76–0.97)

0.95 (0.80–1.13)

  > 6.7

1.38 (1.03–1.85)

1.22 (0.95–1.55)

1.07 (0.90–1.26)

 CVD mortality

  ≤ 6.7

0.77 (0.60–1.00)

0.89 (0.72–1.11)

1.10 (0.85–1.43)

  > 6.7

1.50 (1.13–2.00)

1.33 (1.10–1.60)

1.29 (1.05–1.58)

 Cancer mortality

  Monotonical

0.79 (0.64–0.97)

0.85 (0.72–1.00)

0.80 (0.67–0.96)

Female

 All-cause mortality

  ≤ 5.5

1.16 (0.95–1.42)

0.93 (0.77–1.13)

0.97 (0.77–1.22)

  > 5.5

1.39 (1.24–1.55)

1.24 (1.11–1.37)

1.22 (1.07–1.39)

 CVD mortality

  ≤ 5.5

1.08 (0.74–1.56)

0.95 (0.68–1.33)

0.94 (0.63–1.39)

  > 5.5

1.62 (1.28–2.06)

1.49 (1.13–1.96)

1.62 (1.24–2.13)

 Cancer mortality

  ≤ 5.5

1.26 (0.88–1.80)

1.02 (0.71–1.45)

1.07 (0.63–1.80)

  > 5.5

1.57 (1.18–2.10)

1.72 (1.31–2.28)

1.95 (1.41–2.68)

  1. aModel adjusted for age, sex, race/ethnicity, marital status, education level, occupation type, smoking status, alcohol consumption, physical exercise, BMI, eGFR, triglyceride, total cholesterol, fasting glucose, CRP, and ALT