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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus

Fig. 6

Proposed mechanism triggering EndMT in diabetes-related aortic stiffening. Under diabetic or high glucose conditions, miR-132-3p is downregulated which activates the expression of its target KLF7. KLF7 is upregulated in aortas of both diabetic patients and an in vivo model of diabetes, as well as in high glucose-treated endothelial cells. Moreover, KLF7 co-localizes with the endothelial marker CD31 in diabetic mice, which suggests its contribution to EndMT in diabetes-related aortic stiffening

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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