Fig. 4From: Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?Suggested pathway by which ARBs awoke browning. ARBs selective and competitive type 1 angiotensin II receptor (AT-1) blockers; M2 macrophage type 2, β3-AR β3-adrenergic receptor, AMP adenosine monophosphate, cAMP cyclic adenosine monophosphate, PKA protein kinase A, UCP-1 uncoupling protein-1Back to article page