Fig. 3

Schematic representation of sacubitril/valsartan binding to mTORC1. Structural domains of mTORC1 are presented in different colours: mLST-8 (mammalian lethal with Sec13 protein 8) is coloured green, RAPTOR (regulatory associated protein of mTOR) is coloured gray, serine/threonine-protein kinase mTOR is framed with dashed lines. 4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1) is presented in black letters. Structural domains of mTOR: FRB (rapamycin binding domain) is coloured orange, FAT (trans-activation domain-associated protein domain) is coloured cyan, FATC (C-terminal FAT domain) is coloured blue, while CD C and N lobe (catalytic domain) are coloured magenta and red