Table 2 Effects of different exercise protocols on the expression of circulating and myocardial miR-126, EPCs, EPC-exosomes, and VEGF
From: Roles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetes
Species | Exercise intervention | Exercise Type | The changes of miR-126, EPCs, EPC-exosomes, and VEGF after exercise |
|---|---|---|---|
Healthy individuals | A single symptom-limited exercise test | Bicycling | c-miR-126↑; [56] |
Healthy individuals | HIIT: 3—min 85% of a peak power output, 4—min intervals at 40% PPO, 30 min | Bicycling | c-miR-126↑, endothelial MVs ↔ ; [57] |
Healthy individuals | HIIT: 4 × 30 s all—out, 7: 30 min—intervals at 45% PPO | Bicycling | c-miR-126↑; [58] |
Healthy individuals | HIIT: 95% of a peak power output, 4 × 4 min, 3—min intervals at 45% PPO | Bicycling | c-miR-126↑; [58] |
Healthy individuals | HIIT: 90—95% of a peak power output, 4 × 4 min, 3—min intervals | Bicycling | c-miR-126 ↔ , c-VEGF↑; [59] |
Healthy individuals | A marathon | Running | |
Healthy individuals | HT: 70% of the individual anaerobic threshold, 4 h | Bicycling | c-miR-126↑; [56] |
Healthy individuals | MT: 60% of a peak power output, 30 min | Bicycling | c-miR-126 ↔ , endothelial MVs ↔ ; [57] |
Healthy individuals | MT: 60% V̇O2max, 30 min | Running | EPC↑; [61] |
Healthy individuals | MT: 60% of a peak power output, 90 min; | Bicycling | c-miR-126↑, c-VEGF↑; [59] |
Healthy individuals | MT: 55% of a peak power output, 130 min; | Bicycling | c-miR-126↑; [58] |
Healthy individuals | CE: (4—7) × 30 s, all—out, 30 s intervals at warm—up speed, 3 d/wk × 4 wks | Running | c-miR-126↑; [62] |
Healthy individuals | CE: 4 × 30 s, all—out, 30 s intervals at 8.0 km/h, 2 d/wk × 4 wks | Running | |
Healthy individuals | CE: 74.75% of HRmax, 25 min, 3 d/wk × 4 wks | Running | c-miR-126↑; [62] |
Healthy individuals | CE: 55%—75% V̇O2max, 3 d/wk × 20 wks | Bicycling | c-miR-126↑; [64] |
Healthy individuals | CE: marathon routine training | Running | EPC↑; [65] |
Healthy individuals | 3 sets × 15 repetitions of six machine resistance exercises | RT | |
Healthy individuals | 3 sets × 15 repetitions of three machine resistance exercises | RT | c-miR-126 ↔ ; [56] |
Healthy individuals | 60%, 70% or 80% of 1RM; 12 repetitions × 4 exercises, 30 min | RT | EPC↑, c-VEGF↑; [67] |
Healthy individuals | CE: 3 sets of 10 repetitions × 5, 3 d/wk × 6 wks | RT | c-VEGF↑; [68] |
Healthy individuals | CE: resistance routine training | RT | mu-miR-126↓; [69] |
Obese individuals | HT: 75% V̇O2max, 30 min | Running | c-miR-126↑; [70] |
T2DM patients | MT: 60% V̇O2max, 30 min | Running | EPC ↔ ; [61] |
T2DM patients | Strength training circuit, 30 min and walking at 60%—70% of HRR, 40 min | RT & walking | c-miR-126 ↔ ; [71] |
C57BL/6 J mice | CE: 5 or 10 m/min; 60 min/d, 5 d/wk × 4 wks | Running | EPC↑, EPC-miR-126↑, EPC-exo↑, EPC-exo-miR-126↑; [15] |
db/db mice | CE: 9—13 m/min, 10 × 5 min, a slope of 10°, 5 d/wk × 8 wks | Running | m-miR-126↑, m-VEGF↑, c-miR-126 ↔ ; [72] |
Wistar rats | CE: 60 min/d, 5% body overload, 5 d/wk × 4 wks | Swimming | m-miR-126↑, m-VEGF↑; [73] |
Wistar rats | CE: 60 min/d in 1–8 week; 120 min/d in the 9th week, 180 min/d in the 10th week; 5% body overload, 5 d/wk | Swimming | m-miR-126↑, m-VEGF↑; [73] |
Wistar rats | CE: voluntary exercise, 3000 m/d, 8 wks | Running | m-miR-126↑; [74] |
STZ rats | CE: 95—100% V̇O2max, 6d/wk × 6 wks | Running | m-miR-126↑, m-VEGF↑; [75] |
STZ rats | CE: voluntary exercise, > 2000 m/d; 6 wks | Running | |
STZ rats | CE: 25 m/min, 30 min, a slope of 5%; 8wks | Running | m-miR-126↑, m-VEGF↑; [14] |
STZ rats | CE: 10—39 m/min, 30 min, 5 d/wk × 6 wks | Running | mu-miR-126↑; [77] |
Obese Zucker rats | CE: 4% of body overload, 60 min, 5 d/wk × 10 wks | Swimming | m-miR-126↑, m-VEGF↑; [78] |
SHR rats | CE: 4% of body overload, 60 min, 5 d/wk × 10 wks | Swimming | c-miR-126 ↔ ; [79] |
MI rats | CE: 15 m/min, 3—min × 7 & 25 m/min, 4 min × 7, 5d/wk × 4 wks | Running | m-miR-126↑; [80] |