Table 2 Differences in clinical parameters at week 12 with control vs vildagliptin, mean (SEM) reported
Characteristics | Control | Vildagliptin | Mean difference | P |
|---|---|---|---|---|
Laboratory results | ||||
HBA1c | 9.1 ± 0.3 | 8.1 ± 0.3 | 1.0 | 0.02 |
Protein (total) | 73.2 ± 1.1 | 71 ± 1.2 | 2.3 | 0.20 |
Albumin | 37.0 ± 1.0 | 39.0 ± 1.1 | − 2.1 | 0.20 |
Globulin | 35.7 ± 1.0 | 33.4 ± 1.0 | 2.3 | 0.07 |
Urea/creat | 87.0 ± 5.6 | 82.4 ± 6.1 | 4.6 | 0.60 |
eGFR | 69.5 ± 2.3 | 71.4 ± 2.3 | − 1.8 | 0.60 |
WBC | 9.1 ± 0.4 | 8.0 ± 0.4 | 1.3 | 0.06 |
Neutrophils | 6.1 ± 0.4 | 5.0 ± 0.4 | 1.2 | 0.06 |
Haematocrit | 0.39 ± 0.07 | 0.37 ± 0.07 | 0.02 | 0.04 |
Hb | 130.0 ± 3.0 | 123.0 ± 3.0 | 7.0 | 0.09 |
Platelets | 268.0 ± 20.1 | 265.0 ± 19.2 | 3.0 | 1.00 |
Cholesterol (mmol/L) | 4.3 ± 0.3 | 3.4 ± 0.24 | 0.9 | 0.02 |
Triglycerides (mmol/L) | 2.5 ± 0.4 | 2.1 ± 0.3 | 0.4 | 0.40 |
HDL (mmol/L) | 1.0 ± 0.04 | 1.0 ± 0.03 | 0.005 | 1.00 |
Total/HDL ratio | 5.0 ± 0.3 | 4.0 ± 0.3 | 1.0 | 0.03 |
LDL Chol (mmol/L) | 2.3 ± 0.24 | 1.5 ± 0.23 | 0.8 | 0.04 |
VLDL | 1.0 ± 0.1 | 0.8 ± 0.1 | 0.2 | 0.13 |
Urine creatinine (mg/dL) | 11.9 ± 1.6 | 7.7 ± 1.4 | 4.2 | 0.08 |
Free T4 | 12.0 ± 0.5 | 11.5 ± 0.4 | 0.50 | 0.50 |
FreeT3 | 4.5 ± 0.2 | 4.5 ± 0.20 | − 0.03 | 1.00 |
TSH | 1.6 ± 0.3 | 1.7 ± 0.30 | − 0.05 | 1.00 |
Inflammatory markers | ||||
IL-6 (pg/ml) | 7.1 ± 2.5 | 10.0 ± 3.0 | − 2.9 | 0.50 |
IL-1β (pg/ml) | 150.0 ± 5.6 | 136.0 ± 5.6 | 12.8 | 0.12 |
TNF-α (pg/ml) | 30.0 ± 1.0 | 29.0 ± 1.0 | 0.20 | 1.00 |
Adiponectin (ng/ml) | 11,822.0 ± 2584.0 | 13,138.0 ± 2671.0 | − 1316.0 | 1.00 |
CRP (mg/ml) | 0.12 ± 0.02 | 0.10 ± 0.02 | 0.05 | 0.06 |
TGF-β (pg/ml) | 1053.0 ± 196.0 | 952.0 ± 202.0 | 101.2 | 0.70 |
Ulcer parameters | ||||
Ulcer length mm | 12.2 ± 2.3 | 8.1 ± 2.3 | 4.0 | 0.30 |
Ulcer width mm | 12.4 ± 2.3 | 8.1 ± 2.3 | 4.3 | 0.20 |
Ulcer surface area mm2 | 270.0 ± 94.0 | 128.1 ± 94.0 | 141.0 | 0.30 |
Ulcer depth mm | 2.1 ± 0.5 | 1.4 ± 0.5 | 0.7 | 0.30 |