Table 8 Associations between polymorphism and methylation of the CD36 gene
Variables | Control n = 50 | Obese n = 50 | Obese diabetic n = 50 | |||
|---|---|---|---|---|---|---|
Methylation | Unmethylated | Methylated | Unmethylated | Unmethylated | Unmethylated | Methylated |
SNPs | ||||||
rs1761667 | ||||||
GG | 16 (66.67) | 8 (33.33) | 9 (47.37) | 10 (52.63) | 6 (28.57) | 15 (71.43) |
AA/AG | 21 (80.77) | 5 (19.23) | 9 (29.03) | 22 (70.97) | 16 (55.17) | 13 (44.83) |
Total | 37 (74.00) | 13 (26.00) | 18 (36.00) | 32 (64.00) | 22 (44.00) | 28 (56.00) |
p value | 0.34 | 0.23 | 0.09 | |||
rs3211867 | ||||||
CC | 17 (89.47) | 2 (10.53) | 8 (32.00) | 17 (68.00) | 12 (75.00) | 4 (25.00) |
AA/AC | 20 (64.52) | 11 (35.48) | 10 (40.00) | 15 (60.00) | 10 (29.41) | 24 (70.59) |
Total | 37 (74.00) | 13 (26.00) | 18 (36.00) | 32 (64.00) | 22 (44.00) | 28 (56.00) |
p value | 0.049* | 0.56 | 0.002** | |||
rs1527483 | ||||||
GG | 35 (72.92) | 13 (27.08) | 18 (36.00) | 32 (64.00) | 20 (41.67) | 28 (58.33) |
AA/AG | 2 (100) | – | – | – | 2 (100) | – |
Total | 37 (74.00) | 13 (26.00) | 18 (36.00) | 32 (64.00) | 22 (44.00) | 28 (56.00) |
p value | 0.54 | – | 0.19 | |||