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Table 6 Top twenty overrepresented biological process

From: Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease

Term Count p-value Gene symbol
Positive regulation of glucose import 5 1.70E−09 AKT2, IRS1, IRS2, MAPK14, PIK3R1
Glucose metabolic process 4 7.10E−06 AKT2, G6PD, IRS2, MAPK14,
Cellular response to insulin stimulus 4 1.10E−05 AKT2, IRS1, IRS2, PIK3R1
Insulin receptor signaling pathway 4 1.10E−05 AKT2, IRS1, IRS2, PIK3R1
Positive regulation of fatty acid beta-oxidation 3 1.10E−05 AKT2, IRS1, IRS2
Positive regulation of glucose metabolic process 3 1.10E−05 AKT2, IRS1, IRS2
Positive regulation of glucose import in response to insulin stimulus 3 2.50E−05 AKT2, IRS1, PIK3R1
Positive regulation of glycogen biosynthetic process 3 3.30E−05 AKT2, IRS1, IRS2
Cellular response to lipopolysaccharide 4 3.40E−05 IL12B, IL6, MAPK14, NFKB1
Signal transduction 6 2.90E−04 AKT2, IRS1, IRS2, MAPK14, NFKB1, PIK3R1
Phosphatidylinositol-3-phosphate biosynthetic process 3 3.70E−04 IRS1, IRS2, PIK3R1
Regulation of phosphatidylinositol 3-kinase signaling 3 9.40E−04 IRS1, IRS2, PIK3R1
Phosphatidylinositol phosphorylation 3 1.40E−03 IRS1, IRS2, PIK3R1
Phosphatidylinositol-mediated signaling 3 1.70E−03 IRS1, IRS2, PIK3R1
Positive regulation of transcription from RNA polymerase II promoter 5 1.80E−03 FOXP3, IL6, MAPK14, NFKB1, PIK3R1
Negative regulation of plasma membrane long-chain fatty acid transport 2 2.40E−03 AKT2, IRS2
T cell receptor signaling pathway 3 3.30E−03 FOXP3, NFKB1, PIK3R1
Positive regulation of cell migration 3 5.10E−03 AKT2, IRS2, PIK3R1
Negative regulation of interleukin-17 production 2 6.50E−03 FOXP3, IL12B
Negative regulation of interleukin-10 production 2 7.10E−03 FOXP3, IL12B