Temporal changes in serum uric acid and risk for metabolic syndrome: a longitudinal cohort study

Table 2 Association between baseline SUA levels and incident MetS by gender

Categories	Event/total	Unadjusted Model HR (95%CI) P Value		Model 1 HR (95%CI) P Value		Model 2 HR (95%CI) P Value
Baseline SUA in men
Q1 (< 313 μmol/L)	475/4380	1 (reference)		1 (reference)		1 (reference)
Q2 (313 to < 346 μmol/L)	618/4290	1.38 (1.22, 1.55)	< 0.001	1.41 (1.25, 1.59)	< 0.001	1.38 (1.23, 1.56)	< 0.001
Q3 (346 to < 379 μmol/L)	706/4437	1.57 (1.40, 1.76)	< 0.001	1.60 (1.43, 1.80)	< 0.001	1.53 (1.36, 1.72)	< 0.001
Q4 (379 to < 419 μmol/L)	883/4417	1.97 (1.76, 2.20)	< 0.001	2.01 (1.80, 2.25)	< 0.001	1.91 (1.70, 2.14)	< 0.001
Q5 (≥ 419 μmol/L)	1160/4448	2.73 (2.45, 3.04)	< 0.001	2.77 (2.49, 3.08)	< 0.001	2.59 (2.32, 2.88)	< 0.001
P for trend			< 0.001		< 0.001		< 0.001
Per 10 units increase	3842/21972	1.06 (1.05, 1.06)	< 0.001	1.06 (1.05, 1.06)	< 0.001	1.05 (1.05, 1.06)	< 0.001
Baseline SUA in women
Q1 (< 221 μmol/L)	166/4415	1 (reference)		1 (reference)		1 (reference)
Q2 (221 to < 247 μmol/L)	200/4313	1.19 (0.97, 1.47)	0.094	1.19 (0.96, 1.46)	0.105	1.16 (0.94, 1.43)	0.155
Q3 (247 to < 272 μmol/L)	273/4484	1.59 (1.31, 1.93)	< 0.001	1.53 (1.26, 1.86)	< 0.001	1.51 (1.25, 1.84)	< 0.001
Q4 (272 to < 304 μmol/L)	404/4520	2.43 (2.03, 2.91)	< 0.001	2.25 (1.88, 2.70)	< 0.001	2.17 (1.81, 2.61)	< 0.001
Q5 (≥ 304 μmol/L)	576/4472	3.55 (2.99, 4.22)	< 0.001	2.95 (2.48, 3.52)	< 0.001	2.87 (2.41, 3.43)	< 0.001
P for trend			< 0.001		< 0.001		< 0.001
Per 10 units increase	1619/22204	1.09 (1.08, 1.10)	< 0.001	1.08 (1.07, 1.09)	< 0.001	1.08 (1.07, 1.09)	< 0.001

SUA serum uric acid, MetS metabolic syndrome, CI confidence interval, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, SCr serum creatinine
Model 1: adjusted for baseline age, smoking status, drinking status
Model 2: adjusted for baseline TC, LDL-C and SCr, in addition to covariates in Model 1

ISSN: 1758-5996