Table 3 Meta-analysis of the associations of TLR4Asp299Gly polymorphism with DMI risk
Genetic model | Comparison | Test of association | Test of heterogeneity | ||
|---|---|---|---|---|---|
OR (95% CI) | P-value | P | I2 (%) | ||
Dominant model | G/G + A/G vs A/A | 1.52 (1.10–2.09) | 0.01 | 0.008 | 58.0 |
Allelic model | G vs A | 1.42 (1.02–1.96) | 0.04 | 0.003 | 63.0 |
Recessive model | G/G vs A/G + A/A | 1.87 (0.78–4.46) | 0.16 | 0.94 | 0.0 |
Additive model | G/G vs A/A | 1.94 (0.81–4.61) | 0.14 | 0.94 | 0.0 |
Subgroups | |||||
Ethnicity | |||||
Caucasians | G/G + A/G vs A/A | 1.69 (1.22–2.35) | 0.002 | 0.03 | 54.0 |
G vs A | 1.58 (1.10–2.21) | 0.01 | 0.007 | 62.0 | |
Asians | G/G + A/G vs A/A | 0.85 (0.52–1.39) | 0.52 | 0.46 | 0.0 |
G vs A | 0.89 (0.56–1.39) | 0.60 | 0.47 | 0.0 | |
Difference of DMI types | |||||
Diabetic retinopathy | G/G + A/G vs A/A | 1.81 (1.04–3.14) | 0.03 | 0.004 | 74.0 |
G vs A | 1.77 (1.05–2.98) | 0.03 | 0.004 | 74.0 | |
Diabetic nephropathy | G/G + A/G vs A/A | 1.19 (0.81–1.74) | 0.38 | 0.58 | 0.0 |
G vs A | 0.91 (0.50–1.64) | 0.75 | 0.24 | 31.0 | |
Diabetic neuropathy | G/G + A/G vs A/A | 1.42 (0.76–2.67) | 0.27 | 0.19 | 41.0 |
G vs A | 1.40 (0.80–2.44) | 0.24 | 0.22 | 34.0 | |