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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet

Fig. 6

Schematic of the mechanism of EGCG in attenuating NAFLD. Lipotoxicity induced from HFD can induce ROS, and activating ROS and chronic inflammation suppress FGFR expression, leading to a compensatory increase in FGF21 synthesis and secretion. It can inhibit AMPK pathway and Nrf2 pathway. The damage was reversed after administration of EGCG

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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