Table 1 Demographic characteristics of the studies included
From: Impact of DPP-4 inhibitors on plasma levels of BNP and NT-pro-BNP in type 2 diabetes mellitus
Study, year | Location | Treatment arm (n) | HbA1c (%) | Male (n) | Age (years) | BMI (kg/m2) | Diabetes duration (years) | Treatment duration (months) | BNP/NT-pro-BNP (pg/mL) |
|---|---|---|---|---|---|---|---|---|---|
Oe, 2015 [10] | Multicentre | sita:40 vog:40 | 7.1 ± 0.7 6.9 ± 0.5 | 30 21 | 67.8 ± 10.5 66.7 ± 9.8 | 27.7 ± 4.1 25.7 ± 4.3 | 4.0 ± 1.8 3.2 ± 1.5 | 6 | 39.0 ± 38.0 34.0 ± 35.0 |
Hiramatsu, 2018 [11] | Japan | sita:34 lina:32 lira:32 | 6.7 ± 0.7 6.7 ± 0.7 6.7 ± 0.6 | NS | 69.9 ± 8.5 69.0 ± 7.7 70.5 ± 5.7 | 24.2 ± 3.8 23.8 ± 4.8 23.5 ± 3.5 | 8.3 ± 8.3 8.3 ± 0.4 9.2 ± 7.0 | 48 | 83.9 ± 59.2 90.6 ± 68.6 91.6 ± 69.9 |
Arturi, 2016 [12] | Italy | sita:10 lira:10 glar:12 | 8.3 ± 0.9 8.2 ± 1.0 7.9 ± 0.8 | 6/10 7/10 9/12 | 60.5 ± 10 59.5 ± 9 60 ± 8 | 30.9 ± 2.8 33.2 ± 2.0 30.8 ± 6.0 | NS | 13 | 293.0 ± 46.0 310.0 ± 62.0 296.0 ± 60.0 |
Fadini, 2017 [13] | Italy | lina:22 pla:24 | 7.6 ± 0.2 | 33/46 | 63.7 ± 1.3 | 31.1 ± 0.7 | NS | 0.5 | 101.0 ± 93.2 |
Kitao, 2017 [14] | Multicentre | vild:48 met:48 | 7.3 ± 0.6 7.6 ± 1.1 | 26/48 31/48 | 62.0 ± 14.3 60.0 ± 18.0 | 25.7 ± 4.1 26.1 ± 4.7 | 5.4 ± 3.5 6.5 ± 3.5 | 3 | 31.0 ± 96.0 26.0 ± 68.0 |
Nomoto, 2016 [15] | Multicentre | sita:48 glim:55 | 7.4 ± 0.6 7.4 ± 0.4 | 33 29 | 62.0 ± 15.0 60.0 ± 8.0 | 25.7 ± 3.9 25.2 ± 3.5 | NS | 6.5 | NS |
Phrommintikul, 2019 [16] | Thailand | vild:24 dapa:25 | 8.2 ± 1.2 8.1 ± 1.4 | 12 11 | 63.9 ± 7.6 62.6 ± 8.3 | 24.9 ± 3.2 25.6 ± 3.0 | > 5 | 6 | 955.8 ± 1853.7 399.9 ± 493.1 |
Yamada, 2017 [17] | Multicentre | sita:55 con:60 | 7.0 ± 0.6 6.9 ± 0.5 | 38/55 39/60 | 69.0 ± 8.0 69.0 ± 9.0 | 25.9 ± 3.3 24.8 ± 3.9 | NS | 24 | 111.5 ± 66.2 99.6 ± 60.9 |
Zannad, 2015 [18] | Multicentre | alog:2701 pla:2679 | 8.12 ± 1.12 8.15 ± 1.12 | 1637/2701 1631/2679 | 63.0 ± 4.7 62.0 ± 5.0 | 29.7 ± 2.5 29.5 ± 2.6 | 7.9 ± 13.0 6.8 ± 16.1 | 5 | 699.0 ± 500.7 630.0 ± 472.7 |