An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China

Table 2 Single-SNP association analysis of GDM

Closest gene	SNP	A/a	Control	GDM	OR (95% CI)	P	aOR^a (95% CI)	β^b	P
Closest gene	SNP	A/a	AA/Aa/aa	AA/Aa/aa	OR (95% CI)	P	aOR^a (95% CI)	β^b	P
MTNR1B	rs10830963	C/G	161/239/87	118/246/111	1.327 (1.105–1.592)	0.002	1.387 (1.136–1.694)	0.327	0.001
C2CD4A/B	rs1436953	C/T	236/205/46	194/218/63	1.292 (1.068–1.562)	0.008	1.257 (1.021–1.548)	0.229	0.031
C2CD4A/B	rs7172432	A/G	203/227/57	161/242/72	1.283 (1.062–1.551)	0.010	1.308 (1.061–1.611)	0.268	0.012
CMIP	rs16955379	C/T	250/189/48	268/175/32	1.220 (1.001–1.486)	0.048	1.291 (1.039–1.605)	0.256	0.021

A/a, major allele/minor allele; Risk allele was underlined and in bold
^aThe analysis was adjusted for maternal age, gravidity, parity, BMI, family history of diabetes and way of conception
^bRegression coefficients in the multivariable logistic regression analysis

ISSN: 1758-5996