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Table 2 Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of metabolic syndrome associated with cigarette smoking

From: Association between life-course cigarette smoking and metabolic syndrome: a discovery-replication strategy

Cigarette smoking variables

Discovery stage: TNCHS studya

Replication stage: CHNS studyb

MetS ( +)/All

OR (95%Cl)

P trend c

MetS ( +)/All

OR (95%Cl)

P trend c

Non-smoker

3,063/13,739

Reference

 

1,047/5,977

Reference

–

Smoking status

  

-

  

–

 Ever-smoker

483/1,483

1.62 (1.43–1.84)

512/2588

1.18 (0.10–1.40)

 Former

28/90

1.11 (0.68–1.80)

46/187

0.85 (0.57–1.27)

 Current

455/1,393

1.66 (1.46–1.89)

466/2401

1.22 (1.03–1.45)

Intensity of smoking (cig/day)d

  

 < 0.001

  

0.015

 1–9

90/357

1.10 (0.85–1.43)

81/427

1.05 (0.77–1.42)

 10–19

186/535

1.73 (1.42–2.11)

131/709

1.09 (0.85–1.40)

 20-

207/591

1.91 (1.58–2.31)

300/1,452

1.27 (1.05–1.54)

Smoking durationd

  

 < 0.001

  

0.881

 Tertile 1

143/471

1.46 (1.17–1.82)

156/846

1.51 (1.18–1.93)

 Tertile 2

154/468

1.72 (1.39–2.14)

197/882

1.41 (1.13–1.76)

 Tertile 3

186/544

1.68 (1.38–2.05)

159/860

0.81 (0.64–1.03)

Pack-yearsd

  

 < 0.001

  

0.639

 Tertile 1

132/494

1.18 (0.94–1.46)

160/869

1.25 (0.99–1.58)

 Tertile 2

172/494

1.81 (1.47–2.22)

172/830

1.30 (1.04–1.64)

 Tertile 3

179/495

1.97 (1.61–2.42)

180/889

1.03 (0.82–1.29)

CSI categoriesd

  

 < 0.001

  

0.364

 Tertile 1

132/494

1.19 (0.95–1.48)

161/862

1.30 (1.03–1.65)

 Tertile 2

168/502

1.76 (1.44–2.16)

181/869

1.30 (1.04–1.63)

 Tertile 3

183/487

2.01 (1.64–2.47)

170/857

0.99 (0.78–1.24)

  1. CSI comprehensive smoking index, OR odds ratio, CI confidence interval
  2. aAdjusted for age, physical activity, body mass index, dietary habits
  3. bAdjusted for sex, age, body mass index, province, and region
  4. cLinear trend was tested by entering the median value of each group of cigarette smoking variables as continuous variables in the models
  5. dParticipants were divided into four groups: non-smokers; and the tertiles of CSI in ever smokers. In the TNCHS: the tertile cut-off points were: 39 and 45 for years of smoking, 19 and 36.5 for pack-years, and 1.550 and 1.940 for CSI. In the CHNS: the tertiles cut-off points were: 23 and 35 years for years smoking, 15 and 30 for pack-years, and 1.171 and 1.701 for CSI