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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

Fig. 6

CircSMAD4 regulated BMP7 expression by targeting miR-377-3p. A MiR-377-3p binding to BMP7 3′UTR was predicted by DIANA tools. B The interaction between miR-377-3p and BMP7 was predicted by dual-luciferase reporter assay. C The expression of BMP7 protein in SV40-MES13 cells treated with HG, NG or mannitol was detected by western blot. D The expression of BMP7 protein in SV40-MES13 cells transfected with miR-377-3p or anti-miR-377-3p was measured by western blot. E The expression of BMP7 protein in SV40-MES13 cells transfected with sh-circSMAD4 or sh-circSMAD4 + anti-miR-377-3p was detected by western blot. *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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