Table 4 Assessment of association between SNP + 276 (rs1501299) and risk of type 2 diabetes using subgroup analyses

TT genotype

20

0.87 (0.77, 0.98)

1.84

0.026

38

0.05

 Ethnicity

  Asian

9

0.90 (0.75, 1.08)

− 1.07

0.28

0.00

0.56

  European

9

0.80 (0.67, 0.97)

− 1.58

0.023

60

0.01

  American

2

0.98 (0.72, 1.33)

− 0.29

0.92

60.3

0.11

 Study design

  Case–control

14

0.87 (0.70, 1.08)

− 1.22

0.22

52

0.012

  Cohort

6

0.80 (0.64, 1)

− 1.93

0.05

0.00

0.71

 Sex

  Male

19

0.78 (0.65, 1.03)

− 0.98

0.69

65

0.04

  Female

19

0.82 (0.75, 1.21)

− 0.75

0.61

75

0.02

GT genotype

20

0.79 (0.60, 1.02)

− 1.77

0.07

93.8

< 0.001

 Ethnicity

  Asian

9

0.99 (0.71, 1.3)

− 0.032

0.97

90.3

 < 0.001

  European

9

0.67 (0.42, 1.06)

− 1.70

0.08

95.3

 < 0.001

  American

2

0.61 (0.20, 1.81)

− 0.89

0.37

97.2

 < 0.001

 Study design

  Case–control

14

0.79 (0.59, 1.05)

− 1.5

0.11

93

 < 0.001

  Cohort

6

0.79 (0.43, 1.45)

− 0.75

0.45

95.9

 < 0.001

 Sex

  Male

19

0.76 (0.45, 1.93)

− 1.02

0.76

92

 < 0.001

  Female

19

0.64 (0.37, 1.78)

− 0.96

0. 45

95

 < 0.001

GG genotype

21

0.76 (0.56, 1.04)

-1.6

0.09

96.7

< 0.001

 Ethnicity

  Asian

10

1.04 (0.71, 1.24)

0.23

0.81

95.7

 < 0.001

  European

9

0.57 (0.30, 1.06)

− 1.75

0.08

97.5

 < 0.001

  American

2

0.58 (0.24, 1.40)

− 1.20

0.22

96.4

 < 0.001

 Study design

  Case–control

15

0.75 (0.52, 1.06)

− 1.59

0.11

96.3

 < 0.001

  Cohort

6

0.80 (0.38, 1.68)

− 0.56

0.57

97.7

 < 0.001

 Sex

  Male

20

0.85 (0.62, 1.75)

− 0.76

0.43

90

 < 0.001

  Female

20

0.77 (0.34, 1.32)

− 1.61

0.21

85.4

 < 0.001