Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

Alimi, Mahrokh; Goodarzi, Mohammad Taghi; Nekoei, Mehdi

doi:10.1186/s13098-021-00749-x

Diabetology & Metabolic Syndrome

Table 1 Main characteristics of studies included for investigation of association between SNP − 11377 (rs266729) and risk of type 2 diabetes

From: Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

Author’s name	Country	Study design	Sex ratio (M/F)	Genotyping method	Ethnicity	Target population	Disease	Sample size (Diabetes)	Sample size (control)	Case			Control			P-value for HWE	NOS score
										GG	CG	CC	GG	CG	CC
Zhang et al. [17]	Sweden	Cohort	313/265	DASH	Caucasian	American	T1D	578	599	35	232	310	29	230	340	0.022	7
Hara et al. [18]	Japan	Case–control	267/117	SNaPshot ddNTP	Asian	Japanese	T2D	384	480	24	127	233	37	178	265	0.77	8
Vasseur et al. [19]	France	Case–control	604/769	Ampli-Fluor	Caucasians	French	T2D	1373	743	46	274	300	45	264	382	0.71	8
Gu et al. [20]	Sweden	Case–control	56/50	DASH	Caucasians	Swedish	T2D	106	497	11	34	58	53	186	247	0.25	8
Hu et al. [21]	USA	Nested Case–control	642F	TaqMan	Caucasians	Caucasians	T2D	642	995	41	244	357	59	379	557	0.75	9
Gibson et al. [22]	UK	Case–control	390/422	Ampli-Fluor	Caucasians	French	T2D	812	1044	59	320	433	70	402	572	0.003	7
Vasseur et al. [23]	France	Case–control	115/329	TaqMan	Caucasians	French	T2D	444	535	10	98	123	13	90	167	0.04	8
Tso et al. [24]	Hong Kong	Cohort	76/82	PCR–RFLP	Chinese	Chinese	T2D	50	104	10	62	86	8	44	52	0.1	7
Schwarz et al. [25]	Germany	Cohort	224/191	TaqMan	Caucasians	German	T2D	365	323	35	143	187	20	120	183	0.003	7
Gable et al. [26]	UK	Cohort	169 M	TaqMan	Caucasians	European	T2D	169	2767	15	60	83	175	1038	1440	0.43	6
Olckers et al. [27]	South Africa	Cohort	31/196	TaqMan	Black	South African	T2D	227	226	1	60	166	5	60	161	0.05	6
Sun et al. [28]	China	Case–control	138/117	PCR–RFLP	Chinese	Chinese	T2D	255	120	14	119	122	5	41	74	0.05	7
Hivert et al. [29]	USA	Cohort	515/580	MS	white	white	T2D	1095	1448	11	98	124	146	784	1259	2.52	7
Wang et al. [30]	China	Case–control	394/591	TaqMan	Han Chinese	Han Chinese	T2D	985	1050	79	379	479	61	408	529	2.31	7
Yang et al. [31]	China	Case–control	75/137	PCR–RFLP	Han Chinese	Han Chinese	T2D	212	585	22	90	100	50	210	325	3.6	7
Wang et al. [32]	China	Case–control	196/142	PCR–RFLP	Chinese	Chinese	T2D	338	460	21	101	165	15	161	243	3.53	8
Chiodini et al. [33]	Italy	Cohort	285/218	TaqMan	Italians	Italians	T2D	503	503	22	159	322	22	160	321	0.72	9
Karimi et al. [34]	Iran	Case–control	36/44	PCR–RFLP	Iranian	Iranian	T2D	80	80	2	32	441	1	29	50	0.65	6
Palit et al. [35]	India	Case–control	142/143	PCR–RFLP	Gujarat	Indian	T2D	285	286	148	148	137	131	131	155	0.2	7
Palit et al.	India	Case–control	217/174	PCR–RFLP	Jand K	Indian	T2D	503	290	194	194	309	139	139	151	0.2	8
Ramya et al. [36]	India	Case–control	497/603	PCR–RFLP	South Indian	Indian	T2D	1073	1053	71	71	572	49	383	621	0.004	6
Mtiraoui et al. [37]	Tunisia	Case–control	422/495	TaqMan	Caucasian	Tunisia	T2D	917	748	89	89	4231	50	279	419	5.1	9
Cui et al. [4]	China	Case–control	85/118	IMLDR	Chinese	Chinese	T2D	203	203	10	10	110	15	83	105	0.47	7
Nomani et al. [38]	Iran	Case–control	43/57	PCR–RFLP	Iranian	Iranian	T2D	100	95	3	3	61	1	28	66	0.35	8
Alimi et al. [11]	Iran	Case–control	57/43	Tetra ARMS-PCR	Iranian	Iranian	T2D	100	110	9	9	33	9	46	55	0.041	8
Populaire et al. [39]	Japan	Case–control	82/82	PCR–RFLP		Japanese	T2D	164	183	11	11	105	10	87	86	0.002	6

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