Fig. 6

MiR-98-5p regulated apoptosis and fibrosis of high glucose-treated HPCs and HK-2 cells by targeting NOTCH2. A–H HPCs and HK-2 cells were transfected with inhibitor NC, miR-98-5p inhibitor, miR-98-5p inhibitor + si-NC, or miR-98-5p inhibitor + si-NOTCH2 and then treated with high glucose. A–F The proliferation, apoptosis, and apoptosis-related proteins of HPCs and HK-2 cells under high glucose treatment were evaluated via MTT assay, flow cytometry assay, and western blotting. G, H Protein levels of TGF-β1, FN, and Col.I in HPCs and HK-2 cells under high glucose treatment were measured by western blot analysis. *P < 0.05