Fig. 4

CDKN2B-AS1 regulated apoptosis and fibrosis of high glucose-treated HPCs and HK-2 cells by sponging miR-98-5p. A–H HPCs and HK-2 cells were transfected with si-NC, si-CDKN2B-AS1, si-CDKN2B-AS1 + inhibitor NC, or si-CDKN2B-AS1 + miR-98-5p inhibitor and then treated with high glucose. A–D The proliferation and apoptosis of high glucose-treated HPCs and HK-2 cells was detected by MTT and flow cytometry assays. E–H Protein levels of Bax, Bcl-2, TGF-β1, FN, and Col.I in high glucose-disposed HPCs and HK-2 cells were measured by western blot analysis. *P < 0.05