Fig. 3
The real analytical structure of wide-type Kir6.2 subunit and KATP channel and Kir6.2 subunit and KATP channel carrying KCNJ11 R136C predicted by computer software. A A hydrogen bond is formed between R136 and E126 in wide-type Kir6.2. B The hydrogen bond still exists between R136C and E126 in Kir6.2 subunit carrying KCNJ11 R136C. And the real analytical structure predicted by computer software changes, marked by color yellow. C In wide-type KATP channel, color blue in the middle is potassium ions, which is in the channel port. D In KATP channel carrying KCNJ11 R136C, the amino acid changes from hydrophilic basic amino acid with a positive charge to hydrophilic neutral amino acid, which can change the charge distribution of the channel port and thus affect the function of KATP channel