Fig. 6

HMGA2 downregulation protected against the HG-induced cell dysfunction in HRMCs. A The protein expression of HMGA2 in control, HG, HG + si-NC or HG + si-HMGA2 group was evaluated by western blot. B CCK-8 was performed to analyze cell viability. C ELISA was performed to measure the concentrations of IL-6 and TNF-α. D EdU assay was conducted to determine cell proliferation. E, F Western blot was conducted to detect the protein levels of collagen I and collagen IV. G, H SOD activity (G) and MDA level (H) by the detection kits were exploited to examine the oxidative stress. **P < 0.01, ***P < 0.001, ****P < 0.0001